Antibodies, Assay Kits, cDNA, Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells, Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats, Clia Kits, Culture Cells, Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections., Devices, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Functions of natural killer cells, Gels, General, Healthy Neonates Possess a CD56-Negative NK Cell Population with Reduced Anti-Viral Activity, Human mesenchymal stem cells modulate allogeneic immune cell responses, Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition, Isotypes, Medium & Serums, Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell., Panel, Particles, Pcr Kits, Peptides, Reagents, Ria Kits, RNA, TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells., Vector & Virus

Antigens of Mycobacterium tuberculosis Stimulate CXCR6+ Natural Killer Cells

Natural killer (NK) cells take part in immunity in opposition to a number of pathogens by exerting cytotoxic and cytokine-production actions. Some NK cell subsets additionally mediate recall responses that resemble reminiscence of adaptive lymphocytes in opposition to antigenic and non-antigenic stimuli. The C-X-C motif chemokine receptor 6 (CXCR6) is essential for the event and upkeep of memory-like responses in murine NK cells. In people, a number of subsets of tissue-resident and circulating NK cells with totally different purposeful properties specific CXCR6. However, the function of CXCR6+ NK cells in immunity in opposition to related human pathogens is unknown. Here, we addressed whether or not murine and human CXCR6+ NK cells reply to antigens of Mycobacterium tuberculosis (Mtb). For this function, we evaluated the immunophenotype of hepatic and splenic CXCR6+ NK cells in mice uncovered to a cell-wall (CW) extract of Mtb pressure H37Rv. Also, we characterised the expression of CXCR6 in peripheral NK cells from energetic pulmonary tuberculosis (ATB) sufferers, people with latent TB an infection (LTBI), and wholesome volunteer donors (HD). Furthermore, we evaluated the responses of CXCR6+ NK cells from HD, LTBI, and ATB topics to the in vitro publicity to CW preparations of Mtb H37Rv and Mtb HN878.

Our outcomes confirmed that murine hepatic CXCR6+ NK cells broaden in vivo after consecutive administrations of Mtb H37Rv CW to mice. Remarkably, pooled hepatic and splenic, however not remoted splenic NK cells from handled mice, improve their cytokine manufacturing capability after an in vitro re-challenge with H37Rv CW. In people, CXCR6+ NK cells had been barely detected within the peripheral blood, though barely significative increments within the proportion of CXCR6+, CXCR6+CD49a-, CXCR6+CD49a+, and CXCR6+CD69+ NK cells had been noticed in ATB sufferers as in comparison with HD and LTBI people. In distinction, the growth of CXCR6+CD49a- and CXCR6+CD69+ NK cells in response to the in vitro stimulation with Mtb H37Rv was increased in LTBI people than in ATB sufferers. Finally, we discovered that Mtb HN878 CW generates IFN-γ-producing CXCR6+CD49a+ NK cells. Our outcomes exhibit that antigens of each laboratory-adapted and scientific Mtb strains are stimulating elements for murine and human CXCR6+ NK cells. Future research evaluating the function of CXCR6+ NK cells throughout TB are warranted.

Haploidentical transplantation in sufferers with a number of myeloma making use of pure killer cell alloreactive donors

Disease relapse is a vital downside after allogeneic stem cell transplantations in a number of myeloma (MM). To check the speculation that pure killer (NK) cell alloreactivity within the setting of a haploidentical stem cell transplantation (haploSCT) can cut back the chance of myeloma relapse, we carried out a small potential part 2 examine during which we transplanted poor-risk MM sufferers utilizing a killer cell immunoglobulin-like receptor (KIR)-ligand mismatched haploidentical donor. Patients obtained bone marrow grafts after reduced-intensity conditioning, with post-transplantation cyclophosphamide (PTCY) graft-versus-host-disease (GVHD) prophylaxis. The major endpoint was 1.5-year progression-free survival (PFS); stopping guidelines had been put in in case interim outcomes made a profit of 50% PFS at 1.5 years unlikely.

After inclusion of 12 sufferers, of which 9 had been evaluable for the first endpoint, all sufferers relapsed inside a median time of 90 days. All besides 1 affected person confirmed engraftment, with a median time to neutrophil restoration of 18 (12-30) days. The examine was prematurely terminated primarily based on the predefined stopping guidelines after the inclusion of 12 sufferers. With this small examine, we present that in chemo-resistant myeloma sufferers, NK cell KIR-mismatch just isn’t superior to traditional alloSCT. This technique, nevertheless, can function a platform for brand spanking new remedy ideas.Clinical Trial Registry

Irradiated Tumor Fibroblasts Avoid Immune Recognition and Retain Immunosuppressive Functions Over Natural Killer Cells

Primary Gastrointestinal Involvement in a Case of Extranodal-Extranasal Natural Killer T Cell Lymphoma

Extra-nasal varieties of Extra-nodal pure killer cell lymphoma (ENKL) have been identified with poorer prognoses than nasal kind with the worst responses to remedy. The present work introduces a case of ENKL with GI involvement with no nasal manifestations. We report a 56-year male farmer with fever, productive cough, dyspnea, anorexia, vomiting and chill along with malaise and cachexia of three months period referred to a hospital with acute stomach ache, and was identified as peritonitis because of perforated terminal ileum ulcer earlier than experiencing surgical procedure as a case of acute stomach. The pathologic examine of the related biopsy confirmed “ulceration and necrosis with dense fibrinoleukocytic exudation and granulation tissue formation. CT scan decided a bilateral mass like haziness which was extra more likely to be metastatic.

The evaluation of the earlier pathologic specimens raised Natural Killer/T cell Lymphoma (NKTL), the explanation for which we centered on the affected person’s sinuses and nasal space in addition to nasopharynx. There was no discovering in examination and endoscopy of sinuses. Pathology additionally discovered malignant excessive grade non-Hodgkin T cell lymphoma in specimens obtained from debridement of ulcer at terminal ileum. It additionally confirmed that almost all of the tumor cells had been optimistic for CD3, CD56, CD8, and LCA however damaging for CD19, CD20 and AE1/AE3.

Positive reactions for CD30 had been proven by some cells. CD56, CD3, and CD8 had been expressed by neoplastic cells and CD30 had been optimistic in few cells. Proliferative exercise (Ki67 index) was excessive (60-70%). This was the primary base to diagnose an extra-nodal extra-nasal NK/T cell lymphoma. In conclusion, Intestinal modifications at center age, particularly in males with nonspecific scientific manifestations is very suggested to be studied pathologically and genetically for T cell varieties like CD30 optimistic T cells that are normally engaged in ENKTL.

Antibodies, Assay Kits, cDNA, Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells, Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats, Clia Kits, Culture Cells, Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections., Devices, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Functions of natural killer cells, Gels, General, Healthy Neonates Possess a CD56-Negative NK Cell Population with Reduced Anti-Viral Activity, Human mesenchymal stem cells modulate allogeneic immune cell responses, Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition, Isotypes, Medium & Serums, Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell., Panel, Particles, Pcr Kits, Peptides, Reagents, Ria Kits, RNA, TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells., Vector & Virus

Irradiated Tumor Fibroblasts Avoid Immune Recognition and Retain Immunosuppressive Functions Over Natural Killer Cells

Recent research have demonstrated that radiotherapy is ready to induce anti-tumor immune responses along with mediating direct cytotoxic results. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and take part actively in tumor immunoregulation. However, the capability of CAFs to affect immune responses within the context of radiotherapy continues to be poorly understood. This research was undertaken to find out whether or not ionizing radiation alters the CAF-mediated immunoregulatory results on pure killer (NK) cells. CAFs had been remoted from freshly resected non-small cell lung most cancers tissues, whereas NK cells had been ready from peripheral blood of wholesome donors.

Functional assays to review NK cell immune activation included proliferation charges, expression of cell floor markers, secretion of immunomodulators, cytotoxic assays, in addition to manufacturing of intracellular activation markers reminiscent of perforin and granzyme B. Our information present that CAFs inhibit NK cell activation by lowering their proliferation charges, the cytotoxic capability, the extent of degranulation, and the floor expression of stimulatory receptors, whereas concomitantly enhancing floor expression of inhibitory receptors.

Radiation delivered as single high-dose or in fractioned regimens didn’t reverse the immunosuppressive options exerted by CAFs over NK cells in vitro, regardless of triggering enhanced floor expression of a number of checkpoint ligands on irradiated CAFs. In abstract, CAFs mediate noticeable immune inhibitory results on cytokine-activated NK cells throughout co-culture in a donor-independent method. However, ionizing radiation doesn’t intervene with the CAF-mediated immunosuppressive results.

To study the cross-talk between NK cells and DCs in HCV an infection, we remoted monocytes and NK cells from 20 persistent HCV sufferers and 20 wholesome controls. Monocytes had been used to generate immature DCs which had been pulsed with HCV peptides (core, NS3-NS4 and NS5). Four totally different co-cultures had been carried out: E1: each DCs and NK cells had been from a persistent HCV affected person, E2: NK cells from a wholesome management co-cultured with DCs from a persistent HCV affected person, E3:

NK cells from a persistent HCV affected person co-cultured with DCs cells from a wholesome management and E4: each DCs and NK cells had been from a wholesome management. Using stream cytometry, we assessed the impact of those totally different co-cultures on ranges of maturation markers on DCs and ranges of activation/inhibition markers on NK cells. Results confirmed that peptide pulsed HCV DCs confirmed a maturation defect within the type of decreased HLA-DR, decreased CD86 and elevated CD83 expression particularly when co-cultured with HCV NK.

This was primarily as a result of core peptide pulsing and to a lesser extent as a result of NS5 pulsing whereas there was no impact with NS3-NS4 pulsing. Alternatively, HCV NK cells upregulated each activation and inhibition markers particularly when co-cultured with wholesome DCs. Compared to E2, E1 resulted in greater apoptosis of each NK cells and DCs with the proportion of NK apoptosis greater than that of DCs. Taken collectively, the information point out that HCV an infection impairs NK-DC cross-talk which can be a number one trigger in viral persistence and chronicity. This article is protected by copyright. All rights reserved.

Immune checkpoint molecules in pure killer cells as potential targets for most cancers immunotherapy

Recent research have demonstrated the potential of pure killer (NK) cells in immunotherapy to deal with a number of sorts of most cancers. NK cells are innate lymphoid cells that play important roles in tumor surveillance and management that effectively kill the tumor and don’t require the foremost histocompatibility complicated. The discovery of the NK’s potential as a promising therapeutic goal for most cancers is a reduction to oncologists as they face the problem of elevated chemo-resistant cancers. NK cells present nice potential towards stable and hematologic tumors and have progressively proven promise as a therapeutic goal for most cancers immunotherapy. The effector function of those cells is reliant on the steadiness of inhibitory and activating alerts.

Understanding the function of assorted immune checkpoint molecules within the exhaustion and impairment of NK cells when their inhibitory receptors are excessively expressed is especially necessary in most cancers immunotherapy research and scientific implementation. Emerging immune checkpoint receptors and molecules have been discovered to mediate NK cell dysfunction within the tumor microenvironment; this has introduced up the necessity to discover additional further NK cell-related immune checkpoints which may be exploited to reinforce the immune response to refractory cancers. Accordingly, this evaluate will give attention to the current findings in regards to the roles of immune checkpoint molecules and receptors within the regulation of NK cell operate, in addition to their potential software in tumor immunotherapy.

Irradiated Tumor Fibroblasts Avoid Immune Recognition and Retain Immunosuppressive Functions Over Natural Killer Cells

Natural Killer Cells in Immunotherapy: Are We Nearly There?

atural killer (NK) cells are potent anti-tumor and anti-microbial cells of our innate immune system. They are geared up with an unlimited array of receptors that acknowledge tumor cells and different pathogens. The innate immune exercise of NK cells develops sooner than the adaptive one carried out by T cells, and research counsel an necessary immunoregulatory function for every inhabitants towards the opposite.

The affiliation, noticed in acute myeloid leukemia sufferers receiving haploidentical killer-immunoglobulin-like-receptor-mismatched NK cells, with induction of full remission was the determinant to start an growing variety of scientific research administering NK cells for the therapy of most cancers sufferers. Unfortunately, though transfused NK cells demonstrated security, their noticed efficacy was poor.

Tapered Micro Tips

0-120-0007 3 mm
EUR 344

Tapered Micro Tips 5 mm Diameter Tapered Titanium Micro Tip

0-120-0008 5 mm
EUR 358

10 mm Diameter Solid Titanium Tip

0-120-0009 10 mm
EUR 504

13 mm Diameter Tapped Titanium Tip

0-120-0010 13 mm
EUR 595

13 mm Diameter Solid Titanium Tip

0-120-0011 13 mm
EUR 533

19 mm Diameter Tapped Titanium Tip

0-120-0012 19 mm
EUR 639

19 mm Diameter Solid Titanium Tip

0-120-0013 19 mm
EUR 570

25 mm Diameter Tapped Titanium Tip

0-120-0014 25 mm
EUR 682

25 mm Diameter Solid Titanium Tip

0-120-0015 25 mm
EUR 614

Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip

0-120-0016 13 mm
EUR 86
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip

0-120-0017 19 mm
EUR 92
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip

0-120-0018 25 mm
EUR 100
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Titanium Cup Tip, 250 ml

0-120-0019 250 ml
EUR 1377
Description: includes Interface Washers

Microtube Tray, 8 Position (for 250 ml Cup Tip)

0-120-0021 each
EUR 113
Description: includes Interface Washers

Continuous Flow Chamber

0-120-0026 each
EUR 774
Description: includes Interface Washers

Interface Washers 1.5” Diameter, 5/Pkg

0-120-003 1.5'' Diameter
EUR 31

13 mm Diameter Solid Titanium Extender Tip

0-120-0032 13 mm
EUR 301

13 mm Diameter Tapped Titanium Extender Tip

0-120-0033 13 mm
EUR 362

19 mm Diameter Solid Titanium Extender Tip

0-120-0034 19 mm
EUR 315

19 mm Diameter Tapped Titanium Extender Tip

0-120-0035 19 mm
EUR 375

25 mm Diameter Solid Titanium Extender Tip

0-120-0036 25 mm
EUR 328

25 mm Diameter Tapped Titanium Extender Tip

0-120-0037 25 mm
EUR 389

KoldPod, 1.5ml Micro Tube

0-120-0038 1.5 ml
EUR 152
Description: Thermo conductive tube pods

KoldPod, 15ml Conical Tube

0-120-0039 15 ml
EUR 275
Description: Thermo conductive tube pods

KoldPod, 50ml Conical Tube

0-120-0040 50 ml
EUR 290
Description: Thermo conductive tube pods

Model 150 V/T Ultrasonic Homogenizer

0-121-0002 210-240V/50-60Hz
EUR 2920
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing.

Model 300 V/T Ultrasonic Homogenizer

0-122-0002 210-240V/50-60Hz
EUR 3520
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample.

SONABOZ Sound Abating Chamber

0-125-0001 each
EUR 1020
Description: Reduces cavitational sound emitted during processing.

Model 3000 Ultrasonic Homogenizer

0-127-0002 210-240V/50-60Hz
EUR 4120
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample.

Model 3000MP Ultrasonic Homogenizer

0-128-0002 210-240V/50-60Hz
EUR 4720
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing.

OMNICON® Zone Reader, 210-240V/50-60Hz

0-131-0002 210-240V/50-60Hz
EUR 35200
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media.

OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz

0-134-0002 210-240V/50-60Hz
EUR 32200
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample.

Peni Cylinder Dispenser with Manual Hopper

0-144-0002 each
EUR 5406
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish.

Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz

0-144-0003 100-240V/50-60Hz
EUR 6254
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection.

Stainless Steel Peni Cylinder with Flat Face

0-144-0005 6mm I.D. x 8mm O.D. x 10mm Long
EUR 399
Description: sold in packages of 100 pieces

Stainless Steel Peni Cylinder with Chamfered Face

0-144-0006 6mm I.D. x 8mm O.D. x 10mm Long
EUR 412
Description: sold in packages of 100 pieces

Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA)

000-CUS Custom
EUR 602

Alpha-Bungarotoxin, CF®405S, 500 ug

00002 1UG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s

00002 500uG
EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug

00002-1 EA
EUR 527

Alpha-Bungarotoxin, CF®405S 100ug

00002-100ug 100uG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

00003-1 EA
EUR 527

Alpha-Bungarotoxin, CF®680R 100ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

00004-1 EA
EUR 527

Alpha-Bungarotoxin, CF®640R 100ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

00005-1 EA
EUR 527

Alpha-Bungarotoxin CF®488A 100ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

00006-1 EA
EUR 527

Alpha-Bungarotoxin, CF®568 100ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

00007-1 EA
EUR 527

Alpha-Bungarotoxin CF®594 100ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

00009-1 EA
EUR 527

Alpha-Bungarotoxin, CF®633 100ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1 1MG
EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1-1 EA
EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011 500uG
EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011-1 EA
EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012 500uG
EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012-1 EA
EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug

00013 10ST
EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug

00013-1 EA
EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014 10ST
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015 500uG
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016 10ST
EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016-1 EA
EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug

00017 500uG
EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug

00017-1 EA
EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug

00018-1 EA
EUR 527

Alpha-Bungarotoxin, CF®555 100ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®

00019-100 100g
EUR 91
Description: 79-06-1

Acrylamide, Chemzymes Ultra Pure®

00019-500 500g
EUR 241
Description: 79-06-1

Biotin-cAMP, 1 mg

00020 1MG
EUR 298
Description: N/A

Biotin-cAMP, 1 mg

00020-1 20ST
EUR 298
Description: N/A

Biotin-cAMP, 50 ug

00020-1-1 EA
EUR 414

Biotin-cGMP, 1 mg

00021 1MG
EUR 331
Description: N/A

Biotin-cGMP, 1 mg

00021-1 20ST
EUR 331
Description: N/A

Biotin-cGMP, 20x50 ug

00021-1-1 EA
EUR 447

Cyanine 644-cAMP, 1 mg

00022 1MG
EUR 496
Description: N/A

Cyanine 644-cAMP, 1 mg

00022-1 20ST
EUR 496
Description: N/A

Cyanine 644-cAMP, 20x50 ug

00022-1-1 EA
EUR 647

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023 1MG
EUR 285
Description: N/A

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023-1 EA
EUR 285

Staurosporine

00025 100uG
EUR 100
Description: N/A

Staurosporine

00025-1 EA
EUR 100

Alpha-Bungarotoxin, CF®543, 500 ug

00026 500uG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®543, 500 ug

00026-1 EA
EUR 527

Alpha-Bungarotoxin, CF®543, 100 ug

00026-100ug 1UG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Rhodamine Phalloidin 300U

00027 300
EUR 364
Description: N/A

Rhodamine Phalloidin 300U

00027-1 EA
EUR 364

Biotin-XX-Phalloidin

00028 100U
EUR 466
Description: N/A

Biotin-XX-Phalloidin

00028-1 EA
EUR 466

Fluorescein-Phalloidin

00030 300U
EUR 364
Description: N/A

Fluorescein-Phalloidin

00030-1 EA
EUR 364

Rhodamine 110 Phalloidin

00032 300ST
EUR 364
Description: N/A

Rhodamine 110 Phalloidin

00032-1 EA
EUR 364

Sulforhodamine 101 (Texas Red®) Phalloidin

00033 300EU
EUR 364
Description: N/A

Sulforhodamine 101 (Texas Red®) Phalloidin

00033-1 EA
EUR 364

Phalloidin, CF®405M

00034 300U
EUR 482
Description: N/A

Phalloidin, CF®405M

00034-1 EA
EUR 482

Phalloidin, CF®405M

00034-T 50U
EUR 101
Description: N/A

Phalloidin, CF®405M

00034-T-1 EA
EUR 101

CF®488A-cAMP

00036 100ug
EUR 136
Description: N/A

CF®488A-cAMP

00036-1 EA
EUR 136

CF®640R-cAMP

00037 100ug
EUR 136
Description: N/A

CF®640R-cAMP

00037-1 EA
EUR 136

Phalloidin, CF555

00040 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF®647, 300 U

00041 300U
EUR 482
Description: N/A

Phalloidin, CF®647, 300 U

00041-1 EA
EUR 482

Phalloidin, CF®647, 50 U

00041-T 50U
EUR 101
Description: N/A

Phalloidin, CF®647, 50 U

00041-T-1 EA
EUR 101

Phalloidin, CF®488A, 300 U

00042 300U
EUR 482
Description: N/A

Phalloidin, CF®488A, 300 U

00042-1 EA
EUR 482

Phalloidin, CF®488A, 50 U

00042-T 50U
EUR 101
Description: N/A

In current years, novel research have emerged, combining NK cells with different immunotherapeutic brokers, reminiscent of monoclonal antibodies, which could enhance scientific efficacy. Moreover, genetically-modified NK cells aimed toward arming NK cells with higher efficacy and persistence have appeared as another choice. Here, we evaluate novel pre-clinical and scientific research printed within the final 5 years administering NK cells as a monotherapy and mixed with different brokers, and we additionally evaluate chimeric antigen receptor-modified NK cells for the therapy of most cancers sufferers.

Antibodies, Assay Kits, cDNA, Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells, Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats, Culture Cells, Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections., Devices, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Functions of natural killer cells, Gels, General, Healthy Neonates Possess a CD56-Negative NK Cell Population with Reduced Anti-Viral Activity, Human mesenchymal stem cells modulate allogeneic immune cell responses, Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition, Isotypes, Medium & Serums, Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell., Panel, Particles, Pcr Kits, Peptides, Reagents, Ria Kits, RNA, TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells.

The Role of the Cytoskeleton in Regulating the Natural Killer Cell Immune Response in Health and Disease: From Signaling Dynamics to Function

Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of virally contaminated and malignant cells. The steadiness between activating and inhibitory alerts derived from NK floor receptors govern the NK cell immune response. The cytoskeleton facilitates most NK cell effector capabilities, akin to motility, infiltration, conjugation with goal cells, immunological synapse meeting, and cytotoxicity. Though many research have characterised signaling pathways that promote actin reorganization in immune cells, it isn’t utterly clear how specific cytoskeletal architectures at the immunological synapse promote effector capabilities, and how cytoskeletal dynamics influence downstream signaling pathways and activation.

Moreover, pioneering research using superior imaging methods have solely begun to uncover the architectural complexity dictating the NK cell activation threshold; it’s changing into clear {that a} distinct group of the cytoskeleton and signaling receptors at the NK immunological synapse performs a decisive position in activation and tolerance. Here, we evaluate the roles of the actin cytoskeleton in NK cells. We deal with how actin dynamics influence cytolytic granule secretion, NK cell motility, and NK cell infiltration by way of tissues into inflammatory websites. We can even describe the further cytoskeletal elements, non-muscle Myosin II and microtubules that play pivotal roles in NK cell exercise.

Expression of programmed cell loss of life protein 1 (PD-1) on pure killer (NK) cells has been tough to analyze on human NK cells. By testing industrial clones and novel anti-PD-1 reagents, we discovered expression of practical PD-1 on resting human NK cells in wholesome people and reconstituting NK cells early after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Peripheral blood samples from wholesome people and transplant recipients had been stained for PD-1 expression utilizing the industrial anti-PD-1 clone PD1.3.1.3, fluorescein isothiocyanate (FITC)-labeled pembrolizumab, or an FITC-labeled single-chain variable fragment (scFv) reagent comprised of pembrolizumab.
These reagents recognized low but constant basal PD-1 expression on resting NK cells, a discovering verified by discovering decrease PD-1 transcripts in sorted NK cells in contrast with these in resting or activated T cells. An enhance in PD-1 expression was recognized on paired resting NK cells after allo-HSCT. Blockade of PD-1 on resting NK cells from wholesome donors with pembrolizumab didn’t improve NK operate towards programmed death-ligand 1 (PD-L1)-expressing tumor traces, however blocking with its scFv by-product resulted in a twofold enhance in NK cell degranulation and up to a fourfold enhance in cytokine manufacturing.
In assist of this mechanism, PD-L1 overexpression of Okay562 targets suppressed NK cell operate. Interleukin-15 (IL-15) exercise was potent and couldn’t be additional enhanced by PD-1 blockade. An identical enhance in operate was noticed with scFv PD-1 blockade on resting blood NK cells after allo-HSCT. We determine the practical significance of the PD-1/PD-L1 axis on human NK cells in which blockade or activation to overcome inhibition will improve NK cell-mediated antitumor management. Furthermore, particular emphasis might be positioned on the position of the cytoskeleton in meeting of immunological synapses, and how mutations or downregulation of cytoskeletal accent proteins influence NK cell operate in well being and illness.
The Role of the Cytoskeleton in Regulating the Natural Killer Cell Immune Response in Health and Disease: From Signaling Dynamics to Function

Lack of Viral Load Within Chronic Lymphoproliferative Disorder of Natural Killer Cells: What Is Outside the Leukemic Clone?

 

Large granular lymphocyte leukemias (LGLL) are sustained by proliferating cytotoxic T cells or NK cells, as occurs in Chronic Lymphoproliferative Disorder of Natural Killer cells (CLPD-NK), whose etiology is simply partly understood. Different hypotheses have been proposed on the unique occasions triggering NK cell hyperactivation and transformation, together with a job of viral brokers. In this angle, we revise the traces of proof that steered a pathogenetic position in LGLL of the publicity to retroviruses and that recognized Epstein Barr Virus (EBV) in different NK cell leukemias and lymphomas and deal with the contrasting information about the significance of viral brokers in CLPD-NK.

EBV was detected in aggressive NK leukemias however not in the indolent CLPD-NK, the place seroreactivity towards HTLV-1 retrovirus envelope BA21 protein antigens has been reported in sufferers, though missing clear proof of HTLV an infection. We subsequent current unique outcomes of complete exome sequencing information evaluation that failed to determine viral sequences in CLPD-NK. We not too long ago demonstrated that proliferating NK cells of sufferers harbor a number of somatic lesions probably contributing to maintain NK cell proliferation.

Thus, we discover whether or not “neoantigens” comparable to the BA21 antigen might be generated by aberrancies current in the leukemic clone. In gentle of the literature and new information, we evaluated the intriguing speculation that NK cell activation will be attributable to retroviral brokers situated outdoors the hematopoietic compartment and on the potential mechanisms concerned with the prospects of immunotherapy-based approaches to restrict the progress of NK cells in CLPD-NK illness.

Tapered Micro Tips

0-120-0007 3 mm
EUR 344

Tapered Micro Tips 5 mm Diameter Tapered Titanium Micro Tip

0-120-0008 5 mm
EUR 358

10 mm Diameter Solid Titanium Tip

0-120-0009 10 mm
EUR 504

13 mm Diameter Tapped Titanium Tip

0-120-0010 13 mm
EUR 595

13 mm Diameter Solid Titanium Tip

0-120-0011 13 mm
EUR 533

19 mm Diameter Tapped Titanium Tip

0-120-0012 19 mm
EUR 639

19 mm Diameter Solid Titanium Tip

0-120-0013 19 mm
EUR 570

25 mm Diameter Tapped Titanium Tip

0-120-0014 25 mm
EUR 682

25 mm Diameter Solid Titanium Tip

0-120-0015 25 mm
EUR 614

Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip

0-120-0016 13 mm
EUR 86
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip

0-120-0017 19 mm
EUR 92
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip

0-120-0018 25 mm
EUR 100
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Titanium Cup Tip, 250 ml

0-120-0019 250 ml
EUR 1377
Description: includes Interface Washers

Microtube Tray, 8 Position (for 250 ml Cup Tip)

0-120-0021 each
EUR 113
Description: includes Interface Washers

Continuous Flow Chamber

0-120-0026 each
EUR 774
Description: includes Interface Washers

Interface Washers 1.5” Diameter, 5/Pkg

0-120-003 1.5'' Diameter
EUR 31

13 mm Diameter Solid Titanium Extender Tip

0-120-0032 13 mm
EUR 301

13 mm Diameter Tapped Titanium Extender Tip

0-120-0033 13 mm
EUR 362

19 mm Diameter Solid Titanium Extender Tip

0-120-0034 19 mm
EUR 315

19 mm Diameter Tapped Titanium Extender Tip

0-120-0035 19 mm
EUR 375

25 mm Diameter Solid Titanium Extender Tip

0-120-0036 25 mm
EUR 328

25 mm Diameter Tapped Titanium Extender Tip

0-120-0037 25 mm
EUR 389

KoldPod, 1.5ml Micro Tube

0-120-0038 1.5 ml
EUR 152
Description: Thermo conductive tube pods

KoldPod, 15ml Conical Tube

0-120-0039 15 ml
EUR 275
Description: Thermo conductive tube pods

KoldPod, 50ml Conical Tube

0-120-0040 50 ml
EUR 290
Description: Thermo conductive tube pods

Model 150 V/T Ultrasonic Homogenizer

0-121-0002 210-240V/50-60Hz
EUR 2920
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing.

Model 300 V/T Ultrasonic Homogenizer

0-122-0002 210-240V/50-60Hz
EUR 3520
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample.

SONABOZ Sound Abating Chamber

0-125-0001 each
EUR 1020
Description: Reduces cavitational sound emitted during processing.

Model 3000 Ultrasonic Homogenizer

0-127-0002 210-240V/50-60Hz
EUR 4120
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample.

Model 3000MP Ultrasonic Homogenizer

0-128-0002 210-240V/50-60Hz
EUR 4720
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing.

OMNICON® Zone Reader, 210-240V/50-60Hz

0-131-0002 210-240V/50-60Hz
EUR 35200
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media.

OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz

0-134-0002 210-240V/50-60Hz
EUR 32200
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample.

Peni Cylinder Dispenser with Manual Hopper

0-144-0002 each
EUR 5406
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish.

Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz

0-144-0003 100-240V/50-60Hz
EUR 6254
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection.

Stainless Steel Peni Cylinder with Flat Face

0-144-0005 6mm I.D. x 8mm O.D. x 10mm Long
EUR 399
Description: sold in packages of 100 pieces

Stainless Steel Peni Cylinder with Chamfered Face

0-144-0006 6mm I.D. x 8mm O.D. x 10mm Long
EUR 412
Description: sold in packages of 100 pieces

Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA)

000-CUS Custom
EUR 602

Alpha-Bungarotoxin, CF®405S, 500 ug

00002 1UG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s

00002 500uG
EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug

00002-1 EA
EUR 527

Alpha-Bungarotoxin, CF®405S 100ug

00002-100ug 100uG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

00003-1 EA
EUR 527

Alpha-Bungarotoxin, CF®680R 100ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

00004-1 EA
EUR 527

Alpha-Bungarotoxin, CF®640R 100ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

00005-1 EA
EUR 527

Alpha-Bungarotoxin CF®488A 100ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

00006-1 EA
EUR 527

Alpha-Bungarotoxin, CF®568 100ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

00007-1 EA
EUR 527

Alpha-Bungarotoxin CF®594 100ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

00009-1 EA
EUR 527

Alpha-Bungarotoxin, CF®633 100ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1 1MG
EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1-1 EA
EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011 500uG
EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011-1 EA
EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012 500uG
EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012-1 EA
EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug

00013 10ST
EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug

00013-1 EA
EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014 10ST
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015 500uG
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016 10ST
EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016-1 EA
EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug

00017 500uG
EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug

00017-1 EA
EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug

00018-1 EA
EUR 527

Alpha-Bungarotoxin, CF®555 100ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®

00019-100 100g
EUR 91
Description: 79-06-1

Acrylamide, Chemzymes Ultra Pure®

00019-500 500g
EUR 241
Description: 79-06-1

Biotin-cAMP, 1 mg

00020 1MG
EUR 298
Description: N/A

Biotin-cAMP, 1 mg

00020-1 20ST
EUR 298
Description: N/A

Biotin-cAMP, 50 ug

00020-1-1 EA
EUR 414

Biotin-cGMP, 1 mg

00021 1MG
EUR 331
Description: N/A

Biotin-cGMP, 1 mg

00021-1 20ST
EUR 331
Description: N/A

Biotin-cGMP, 20x50 ug

00021-1-1 EA
EUR 447

Cyanine 644-cAMP, 1 mg

00022 1MG
EUR 496
Description: N/A

Cyanine 644-cAMP, 1 mg

00022-1 20ST
EUR 496
Description: N/A

Cyanine 644-cAMP, 20x50 ug

00022-1-1 EA
EUR 647

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023 1MG
EUR 285
Description: N/A

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023-1 EA
EUR 285

Staurosporine

00025 100uG
EUR 100
Description: N/A

Staurosporine

00025-1 EA
EUR 100

Alpha-Bungarotoxin, CF®543, 500 ug

00026 500uG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®543, 500 ug

00026-1 EA
EUR 527

Alpha-Bungarotoxin, CF®543, 100 ug

00026-100ug 1UG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Rhodamine Phalloidin 300U

00027 300
EUR 364
Description: N/A

Rhodamine Phalloidin 300U

00027-1 EA
EUR 364

Biotin-XX-Phalloidin

00028 100U
EUR 466
Description: N/A

Biotin-XX-Phalloidin

00028-1 EA
EUR 466

Fluorescein-Phalloidin

00030 300U
EUR 364
Description: N/A

Fluorescein-Phalloidin

00030-1 EA
EUR 364

Rhodamine 110 Phalloidin

00032 300ST
EUR 364
Description: N/A

Rhodamine 110 Phalloidin

00032-1 EA
EUR 364

Sulforhodamine 101 (Texas Red®) Phalloidin

00033 300EU
EUR 364
Description: N/A

Sulforhodamine 101 (Texas Red®) Phalloidin

00033-1 EA
EUR 364

Phalloidin, CF®405M

00034 300U
EUR 482
Description: N/A

Phalloidin, CF®405M

00034-1 EA
EUR 482

Phalloidin, CF®405M

00034-T 50U
EUR 101
Description: N/A

Phalloidin, CF®405M

00034-T-1 EA
EUR 101

CF®488A-cAMP

00036 100ug
EUR 136
Description: N/A

CF®488A-cAMP

00036-1 EA
EUR 136

CF®640R-cAMP

00037 100ug
EUR 136
Description: N/A

CF®640R-cAMP

00037-1 EA
EUR 136

Phalloidin, CF555

00040 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF®647, 300 U

00041 300U
EUR 482
Description: N/A

Phalloidin, CF®647, 300 U

00041-1 EA
EUR 482

Phalloidin, CF®647, 50 U

00041-T 50U
EUR 101
Description: N/A

Phalloidin, CF®647, 50 U

00041-T-1 EA
EUR 101

Phalloidin, CF®488A, 300 U

00042 300U
EUR 482
Description: N/A

Phalloidin, CF®488A, 300 U

00042-1 EA
EUR 482

Phalloidin, CF®488A, 50 U

00042-T 50U
EUR 101
Description: N/A

Phalloidin, CF®488A, 50 U

00042-T-1 EA
EUR 101

Phalloidin, CF®543, 300 U

00043 300U
EUR 482
Description: N/A

Phalloidin, CF®543, 300 U

00043-1 EA
EUR 482

Phalloidin, CF®543, 50 U

00043-T 50U
EUR 101
Description: N/A

Phalloidin, CF®543, 50 U

00043-T-1 EA
EUR 101

Phalloidin, CF®568, 300 U

00044 300U
EUR 482
Description: N/A

Phalloidin, CF®568, 300 U

00044-1 EA
EUR 482

Phalloidin, CF®568, 50 U

00044-T 50U
EUR 101
Description: N/A

Phalloidin, CF®568, 50 U

00044-T-1 EA
EUR 101

This part 2 research with Simon’s two-stage design evaluated daratumumab in sufferers with histologically confirmed extranodal NKTCL, nasal kind, per WHO classification that was refractory to or relapsed after ≥ 1 line of chemotherapy, who weren’t candidates for different remedy modalities. All sufferers obtained daratumumab 16 mg/kg intravenously as soon as weekly for Cycles 1 and 2, each different week for Cycles Three by way of 6, and each four weeks thereafter till development or unacceptable toxicity; all cycles had been 28 days. The main finish level was goal response price (ORR) based mostly on blinded impartial central evaluate per Revised Criteria for Response Assessment of Hodgkin and non-Hodgkin Lymphoma (Lugano classification).

Antibodies, Assay Kits, cDNA, Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells, Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats, Clia Kits, Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections., Devices, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Functions of natural killer cells, Gels, General, Healthy Neonates Possess a CD56-Negative NK Cell Population with Reduced Anti-Viral Activity, Human mesenchymal stem cells modulate allogeneic immune cell responses, Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition, Isotypes, Medium & Serums, Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell., Panel, Particles, Pcr Kits, Peptides, Reagents, Ria Kits, RNA, TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells., Vector & Virus

Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival

The function of PI3K-mTOR pathway in regulating NK cell improvement has been extensively reported. However, it stays unclear whether or not NK cell improvement depends upon the protein kinase B (PKB), which hyperlinks PI3K and mTOR, maybe because of the potential redundancy of PKB. PKB has two phosphorylation websites, threonine 308 (T308) and serine 473 (S473), which may be phosphorylated by phosphoinositide-dependent protein kinase-1 (PDK1) and mTORC2, respectively. In this research, we established a mouse mannequin wherein PKB was inactivated by the deletion of PDK1 and Rictor, a key element of mTORC2, respectively.

We discovered that the only deletion of PDK1 or Rictor may result in a major defect in NK cell improvement, whereas mixed deletion of PDK1 and Rictor severely hindered NK cell improvement on the early stage. Notably, ectopic expression of myristoylated PKB considerably rescued this defect. In phrases of mechanism, in PDK1/Rictor-deficient NK cells, E4BP4, a transcription issue for NK cell improvement, was much less expressed, and the exogenous provide of E4BP4 may alleviate the developmental defect of NK cell in these mice. Besides, overexpression of Bcl-2 additionally helped the survival of PDK1/Rictor-deficient NK cells, suggesting an anti-apoptotic function of PKB in NK cells.

Natural killer (NK) cells and dendritic cells (DCs) are essential mediators of productive immune responses to an infection and illness. NK cells and a subtype of DCs, the kind 1 standard DCs (cDC1s), are individually essential for regulating immune responses to most cancers in mice and people. Recent work has discovered that NK cells and cDC1s interact in intercellular cross-talk integral to initiating and coordinating adaptive immunity to most cancers. This NK cell-cDC1 axis has been linked to elevated total survival and responses to anti-PD-1 immunotherapy in metastatic melanoma sufferers. Here, we evaluation latest findings on the function of NK cells and cDC1s in protecting immune responses to most cancers and immunotherapy, in addition to present therapies concentrating on this NK cell-cDC1 axis.

Further, we discover the idea that intercellular cross-talk between NK cells and cDC1s could also be key for many of the optimistic prognostic associations seen with NK cells and DCs individually. It is evident that rising our understanding of the NK cell-cDC1 innate immune cell axis shall be essential for the era of novel therapies that may modulate anti-cancer immunity and improve affected person responses to frequent immunotherapies. In abstract, full phosphorylation of PKB at T308 and S473 by PDK1 and mTORC2 is important for optimum NK cell improvement, and PKB regulates NK cell improvement by selling E4BP4 expression and stopping cell apoptosis.

Updating targets for pure killer/T-cell lymphoma immunotherapy

 

Natural killer/T-cell lymphoma (NKTCL) is a extremely invasive subtype of non-Hodgkin lymphoma, usually optimistic for cytoplasmic CD3, CD56, cytotoxic markers, together with granzyme B and TIA1, and Epstein-Barr virus (EBV). The present remedy strategies for NKTCL are related to a number of drawbacks. For instance, chemotherapy can result in drug resistance, whereas remedy with radiotherapy alone is insufficient and leads to frequent relapses.

Moreover, hematopoietic stem cell transplantation reveals restricted efficacy and shouldn’t be effectively acknowledged by home and international specialists. In latest years, immunotherapy has proven good medical outcomes and has grow to be a scorching spot in most cancers analysis. Clinical exercise of focused antibodies, equivalent to daratumumab (anti-CD38 antibody) and brentuximab vedotin (anti-CD30 antibody), have been reported in NKTCL. Additionally, dacetuzumab and Campath-1H have demonstrated promising outcomes. Further encouraging knowledge have been obtained utilizing checkpoint inhibitors.

The success of these immunotherapy brokers is attributed to excessive expression ranges of programmed death-ligand 1 in NKTCL. Furthermore, anti-CCR4 monoclonal antibodies (mAbs) exert cytotoxic actions on each CCR4+ tumor cells and regulatory T cells. Depletion of these cells and the lengthy half-life of anti-CCR4 mAbs end in enhanced induction of antitumor effector T cells. The function of IL10 in NKTCL has additionally been investigated. It has been proposed that exploitation of this cytokine may present potential novel therapeutic methods.

Cellular immunotherapy with engineered cytotoxic T lymphocytes focused towards LMP1 and LMP2 has proven promising outcomes and sustained remission. Cellular immunotherapy could also be used both as upkeep remedy following preliminary induction chemotherapy or in instances of relapsed/refractory illness. The current evaluation outlines the recognized immunotherapy targets for the remedy of NKTCL. This enrichment has had substantial enter by inhabitants admixture with neighboring populations, who contributed HLA class I haplotypes expressing the KIR ligands B*46:01 and B*58:01, which subsequently rose to excessive frequency by pure choice.

Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival

Adaptive Admixture of HLA class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians

Human pure killer (NK) cells are important for controlling an infection, most cancers and fetal improvement. NK cell features are modulated by interactions between polymorphic inhibitory killer cell immunoglobulin-like receptors (KIR) and polymorphic HLA-A, -B and -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand and contribute to replica and immunity. In distinction, just some HLA-A and -B alleles encode KIR ligands and they give attention to immunity. By high-resolution evaluation of KIR and HLA-A, -B and -C genes, we present that the Chinese Southern Han are considerably enriched for interactions between inhibitory KIR and HLA-A and -B.

13 mm Diameter Solid Titanium Tip

0-120-0011 13 mm
EUR 533

19 mm Diameter Tapped Titanium Tip

0-120-0012 19 mm
EUR 639

19 mm Diameter Solid Titanium Tip

0-120-0013 19 mm
EUR 570

25 mm Diameter Tapped Titanium Tip

0-120-0014 25 mm
EUR 682

25 mm Diameter Solid Titanium Tip

0-120-0015 25 mm
EUR 614

Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip

0-120-0016 13 mm
EUR 86
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip

0-120-0017 19 mm
EUR 92
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip

0-120-0018 25 mm
EUR 100
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Titanium Cup Tip, 250 ml

0-120-0019 250 ml
EUR 1377
Description: includes Interface Washers

Microtube Tray, 8 Position (for 250 ml Cup Tip)

0-120-0021 each
EUR 113
Description: includes Interface Washers

Continuous Flow Chamber

0-120-0026 each
EUR 774
Description: includes Interface Washers

Interface Washers 1.5” Diameter, 5/Pkg

0-120-003 1.5'' Diameter
EUR 31

13 mm Diameter Solid Titanium Extender Tip

0-120-0032 13 mm
EUR 301

13 mm Diameter Tapped Titanium Extender Tip

0-120-0033 13 mm
EUR 362

19 mm Diameter Solid Titanium Extender Tip

0-120-0034 19 mm
EUR 315

19 mm Diameter Tapped Titanium Extender Tip

0-120-0035 19 mm
EUR 375

25 mm Diameter Solid Titanium Extender Tip

0-120-0036 25 mm
EUR 328

25 mm Diameter Tapped Titanium Extender Tip

0-120-0037 25 mm
EUR 389

KoldPod, 1.5ml Micro Tube

0-120-0038 1.5 ml
EUR 152
Description: Thermo conductive tube pods

KoldPod, 15ml Conical Tube

0-120-0039 15 ml
EUR 275
Description: Thermo conductive tube pods

KoldPod, 50ml Conical Tube

0-120-0040 50 ml
EUR 290
Description: Thermo conductive tube pods

Model 150 V/T Ultrasonic Homogenizer

0-121-0002 210-240V/50-60Hz
EUR 2920
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing.

Model 300 V/T Ultrasonic Homogenizer

0-122-0002 210-240V/50-60Hz
EUR 3520
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample.

SONABOZ Sound Abating Chamber

0-125-0001 each
EUR 1020
Description: Reduces cavitational sound emitted during processing.

Model 3000 Ultrasonic Homogenizer

0-127-0002 210-240V/50-60Hz
EUR 4120
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample.

Model 3000MP Ultrasonic Homogenizer

0-128-0002 210-240V/50-60Hz
EUR 4720
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing.

OMNICON® Zone Reader, 210-240V/50-60Hz

0-131-0002 210-240V/50-60Hz
EUR 35200
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media.

OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz

0-134-0002 210-240V/50-60Hz
EUR 32200
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample.

Peni Cylinder Dispenser with Manual Hopper

0-144-0002 each
EUR 5406
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish.

Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz

0-144-0003 100-240V/50-60Hz
EUR 6254
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection.

Stainless Steel Peni Cylinder with Flat Face

0-144-0005 6mm I.D. x 8mm O.D. x 10mm Long
EUR 399
Description: sold in packages of 100 pieces

Stainless Steel Peni Cylinder with Chamfered Face

0-144-0006 6mm I.D. x 8mm O.D. x 10mm Long
EUR 412
Description: sold in packages of 100 pieces

Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA)

000-CUS Custom
EUR 602

Alpha-Bungarotoxin, CF®405S, 500 ug

00002 1UG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s

00002 500uG
EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug

00002-1 EA
EUR 527

Alpha-Bungarotoxin, CF®405S 100ug

00002-100ug 100uG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

00003-1 EA
EUR 527

Alpha-Bungarotoxin, CF®680R 100ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

00004-1 EA
EUR 527

Alpha-Bungarotoxin, CF®640R 100ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

00005-1 EA
EUR 527

Alpha-Bungarotoxin CF®488A 100ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

00006-1 EA
EUR 527

Alpha-Bungarotoxin, CF®568 100ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

00007-1 EA
EUR 527

Alpha-Bungarotoxin CF®594 100ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

00009-1 EA
EUR 527

Alpha-Bungarotoxin, CF®633 100ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1 1MG
EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1-1 EA
EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011 500uG
EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011-1 EA
EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012 500uG
EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012-1 EA
EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug

00013 10ST
EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug

00013-1 EA
EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014 10ST
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015 500uG
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016 10ST
EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016-1 EA
EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug

00017 500uG
EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug

00017-1 EA
EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug

00018-1 EA
EUR 527

Alpha-Bungarotoxin, CF®555 100ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®

00019-100 100g
EUR 91
Description: 79-06-1

Acrylamide, Chemzymes Ultra Pure®

00019-500 500g
EUR 241
Description: 79-06-1

Biotin-cAMP, 1 mg

00020 1MG
EUR 298
Description: N/A

Biotin-cAMP, 1 mg

00020-1 20ST
EUR 298
Description: N/A

Biotin-cAMP, 50 ug

00020-1-1 EA
EUR 414

Biotin-cGMP, 1 mg

00021 1MG
EUR 331
Description: N/A

Biotin-cGMP, 1 mg

00021-1 20ST
EUR 331
Description: N/A

Biotin-cGMP, 20x50 ug

00021-1-1 EA
EUR 447

Cyanine 644-cAMP, 1 mg

00022 1MG
EUR 496
Description: N/A

Cyanine 644-cAMP, 1 mg

00022-1 20ST
EUR 496
Description: N/A

Cyanine 644-cAMP, 20x50 ug

00022-1-1 EA
EUR 647

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023 1MG
EUR 285
Description: N/A

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023-1 EA
EUR 285

Staurosporine

00025 100uG
EUR 100
Description: N/A

Staurosporine

00025-1 EA
EUR 100

Alpha-Bungarotoxin, CF®543, 500 ug

00026 500uG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®543, 500 ug

00026-1 EA
EUR 527

Alpha-Bungarotoxin, CF®543, 100 ug

00026-100ug 1UG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Rhodamine Phalloidin 300U

00027 300
EUR 364
Description: N/A

Rhodamine Phalloidin 300U

00027-1 EA
EUR 364

Biotin-XX-Phalloidin

00028 100U
EUR 466
Description: N/A

Biotin-XX-Phalloidin

00028-1 EA
EUR 466

Fluorescein-Phalloidin

00030 300U
EUR 364
Description: N/A

Fluorescein-Phalloidin

00030-1 EA
EUR 364

Rhodamine 110 Phalloidin

00032 300ST
EUR 364
Description: N/A

Rhodamine 110 Phalloidin

00032-1 EA
EUR 364

Sulforhodamine 101 (Texas Red®) Phalloidin

00033 300EU
EUR 364
Description: N/A

Sulforhodamine 101 (Texas Red®) Phalloidin

00033-1 EA
EUR 364

Phalloidin, CF®405M

00034 300U
EUR 482
Description: N/A

Phalloidin, CF®405M

00034-1 EA
EUR 482

Phalloidin, CF®405M

00034-T 50U
EUR 101
Description: N/A

Phalloidin, CF®405M

00034-T-1 EA
EUR 101

CF®488A-cAMP

00036 100ug
EUR 136
Description: N/A

CF®488A-cAMP

00036-1 EA
EUR 136

CF®640R-cAMP

00037 100ug
EUR 136
Description: N/A

CF®640R-cAMP

00037-1 EA
EUR 136

Phalloidin, CF555

00040 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF®647, 300 U

00041 300U
EUR 482
Description: N/A

Phalloidin, CF®647, 300 U

00041-1 EA
EUR 482

Phalloidin, CF®647, 50 U

00041-T 50U
EUR 101
Description: N/A

Phalloidin, CF®647, 50 U

00041-T-1 EA
EUR 101

Phalloidin, CF®488A, 300 U

00042 300U
EUR 482
Description: N/A

Phalloidin, CF®488A, 300 U

00042-1 EA
EUR 482

Phalloidin, CF®488A, 50 U

00042-T 50U
EUR 101
Description: N/A

Phalloidin, CF®488A, 50 U

00042-T-1 EA
EUR 101

Phalloidin, CF®543, 300 U

00043 300U
EUR 482
Description: N/A

Phalloidin, CF®543, 300 U

00043-1 EA
EUR 482

Phalloidin, CF®543, 50 U

00043-T 50U
EUR 101
Description: N/A

Phalloidin, CF®543, 50 U

00043-T-1 EA
EUR 101

Phalloidin, CF®568, 300 U

00044 300U
EUR 482
Description: N/A

Phalloidin, CF®568, 300 U

00044-1 EA
EUR 482

Phalloidin, CF®568, 50 U

00044-T 50U
EUR 101
Description: N/A

Phalloidin, CF®568, 50 U

00044-T-1 EA
EUR 101

Phalloidin, CF®594, 300 U

00045 300U
EUR 482
Description: N/A

Phalloidin, CF®594, 300 U

00045-1 EA
EUR 482

Phalloidin, CF®594, 50 U

00045-T 50U
EUR 101
Description: N/A

Phalloidin, CF®594, 50 U

00045-T-1 EA
EUR 101

Phalloidin, CF®633, 300 U

00046 300U
EUR 482
Description: N/A

Phalloidin, CF®633, 300 U

00046-1 EA
EUR 482

Phalloidin, CF®633, 50 U

00046-T 50U
EUR 101
Description: N/A

Phalloidin, CF®633, 50 U

00046-T-1 EA
EUR 101

Phalloidin, CF®660R, 300 U

00047 300U
EUR 482
Description: N/A

Phalloidin, CF®660R, 300 U

00047-1 EA
EUR 482

Phalloidin, CF®660R, 50 U

00047-T 50U
EUR 101
Description: N/A

Phalloidin, CF®660R, 50 U

00047-T-1 EA
EUR 101

Phalloidin, CF®680R, 300 U

00048 300U
EUR 513
Description: N/A

Phalloidin, CF®680R, 300 U

00048-1 EA
EUR 513

Phalloidin, CF®680R, 50 U

00048-T 50U
EUR 101
Description: N/A

Phalloidin, CF®680R, 50 U

00048-T-1 EA
EUR 101

Phalloidin, CF®350, 300 U

00049 300U
EUR 482
Description: N/A

Phalloidin, CF®350, 300 U

00049-1 EA
EUR 482

Phalloidin, CF®350, 50 U

00049-T 50U
EUR 101
Description: N/A

Phalloidin, CF®350, 50 U

00049-T-1 EA
EUR 101

Phalloidin, CF®640R, 300 U

00050 300U
EUR 482
Description: N/A

Phalloidin, CF®640R, 300 U

00050-1 EA
EUR 482

Phalloidin, CF®640R, 50 U

00050-T 50U
EUR 101
Description: N/A

Phalloidin, CF®640R, 50 U

00050-T-1 EA
EUR 101

Phalloidin, CF®532, 300 U

00051 300U
EUR 482
Description: N/A

Phalloidin, CF®532, 300 U

00051-1 EA
EUR 482

Phalloidin, CF®532, 50 U

00051-T 50U
EUR 101
Description: N/A

Phalloidin, CF®532, 50 U

00051-T-1 EA
EUR 101

Phalloidin, CF®660C, 300 U

00052 300U
EUR 482
Description: N/A

Consequently, over 80% of Southern Han HLA haplotypes encode a couple of KIR ligand. Complementing the excessive quantity of KIR ligands, the Chinese Southern Han KIR locus combines a excessive frequency of genes expressing potent inhibitory KIR, with a low frequency of these expressing activating KIR. The Southern Han centromeric KIR area encodes sturdy, conserved, inhibitory HLA-C particular receptors, and the telomeric area offers a excessive quantity and range of inhibitory HLA-A and -B particular receptors. In all these traits, the Chinese Southern Han signify different East Asians, whose NK cell repertoires are thus enhanced in amount, range and effector power, doubtless augmenting resistance to endemic viral infections.

Antibodies, Assay Kits, cDNA, Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells, Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats, Clia Kits, Culture Cells, Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections., Devices, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Functions of natural killer cells, Gels, General, Healthy Neonates Possess a CD56-Negative NK Cell Population with Reduced Anti-Viral Activity, Human mesenchymal stem cells modulate allogeneic immune cell responses, Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition, Isotypes, Medium & Serums, Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell., Panel, Particles, Pcr Kits, Peptides, Reagents, Ria Kits, RNA, TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells., Vector & Virus

Host genetic control of natural killer cell diversity revealed in the Collaborative Cross

Natural killer (NK) cells are innate effectors armed with cytotoxic and cytokine-secreting capacities whose spontaneous antitumor exercise is vital to quite a few immunotherapeutic methods. However, present mouse fashions fail to reflect the in depth immune system variation that exists in the human inhabitants which can impression on NK cell-based therapies. We carried out a complete profiling of NK cells in the Collaborative Cross (CC), a set of novel recombinant inbred mouse strains whose genetic diversity matches that of people, thereby offering a novel and extremely various small animal mannequin for the research of immune variation.

We exhibit that NK cells from CC strains displayed a breadth of phenotypic and useful variation reminiscent of that reported for people on the subject of cell numbers, key marker expression, and useful capacities. We took benefit of the huge genetic diversity of the CC and recognized 9 genomic loci via quantitative trait locus mapping driving these phenotypic variations. SNP haplotype patterns and variant impact analyses recognized candidate genes related to lung NK cell numbers, frequencies of CD94+ NK cells, and expression ranges of NKp46.

Thus, we exhibit that the CC represents an impressive useful resource to check NK cell diversity and its regulation by host genetics.Natural killer (NK) cells, as a possible supply for off-the-shelf cell remedy, assault tumor cells with low danger of extreme cytokine launch syndrome (CRS) or graft-versus-host illness (GvHD). Fcγ receptor IIIA, also referred to as CD16, additional confers NK cells with antibody-dependent cell-mediated cytotoxicity (ADCC), one mechanism of motion of antibody-based immunotherapy.

Here, we set up a novel human NK cell line, oNK-1, endogenously expressing CD16 together with excessive ranges of NK activation markers and low ranges of NK inhibitory markers. The long-term growth and CD16 expression of oNK-1 cells had been demonstrated. Furthermore, oNK-1 cells elicit superior cytotoxicity in opposition to most cancers cells than major NK cells. In conclusion, this research means that endogenous CD16-expressing oNK-1 has the potential to develop an efficient NK-based remedy.

Core 2 β1,6-N-acetylglucosaminyltransferases speed up the escape of choriocarcinoma from natural killer cell immunity

 

Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and incorporates a core2 O-glycan shaped by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT). Choriocarcinoma is taken into account immunogenic as it’s gestational and incorporates paternal chromosomal elements. Here we examined the perform of C2GnT in the evasion of choriocarcinoma cells from natural killer (NK) cell-mediating killing. We decided that C2GnT is very expressed in malignant gestational trophoblastic neoplasms.

C2GnT KO downregulates core2 O-glycan expression in choriocarcinoma cells, that are extra effectively killed by NK cells than control cells. C2GnT KO cell containing tumor necrosis factor-related apoptosis inducing ligand have decrease viability than control cells. Additionally, poly-N-acetyllactosamine in core2 branched oligosaccharides on MHC class I-related chain A (MICA) and mucin1 (MUC1) is considerably decreased in C2GnT KO cells. Meanwhile, the cumulative survival price of nude mice inoculated with C2GnT KO tumors was greater than that of the control group. These findings counsel that choriocarcinoma cells might escape NK cell-mediated killing by way of glycosylation of MICA and MUC1.

Invariant Natural Killer T (iNKT) cells are innate-like T Lymphocytes expressing a conserved semi-invariant T cell receptor (TCR) particular for self or microbial lipid antigens introduced by the non-polymorphic MHC class I-related molecule CD1d. Preclinical and medical research assist a task for iNKT cells in most cancers, autoimmunity and infectious ailments. iNKT cells are very conserved all through species and their investigation has been facilitated by mouse fashions, together with CD1d-deficient or iNKT-deficient mice, and the chance to unequivocally detect them in mice and males with CD1d tetramers or mAbs particular for the semi-invariant TCR.

However, iNKT cells are uncommon they usually must be expanded to succeed in manageable numbers for any research. Because the era of major mouse iNKT cell line in vitro has confirmed troublesome, now we have arrange a sturdy protocol to purify and increase splenic iNKT cells from the iVα14-Jα18 transgenic mice (iVα14Tg), in which iNKT cells are 30 instances extra frequent. We present right here that major splenic iVα14Tg iNKT cells could be enriched via an immunomagnetic separation course of, yielding about 95-98% pure iNKT cells.

Host genetic control of natural killer cell diversity revealed in the Collaborative Cross

Leukemia Inhibitory Factor Suppresses NKG2D mRNA Expression and Presentation on Human Natural Killer Cells

Leukemia inhibitory issue (LIF) is a multi-functional cytokine secreted from cells corresponding to lymphocytes and hepatocytes. This research aimed to judge the impact of LIF on natural killer group 2 member D (NKG2D) receptors’ expression and presentation on natural killer (NK) cells. For this function, peripheral blood mononuclear cells taken from four younger male wholesome blood donors had been remoted and the impact of LIF (25 ng/mL) after 12, 24, and 48 hours of incubation, on NKG2D receptors expression and presentation was investigated utilizing circulation cytometry and real-time-polymerase chain response (PCR).

10 mm Diameter Solid Titanium Tip

0-120-0009 10 mm
EUR 504

13 mm Diameter Tapped Titanium Tip

0-120-0010 13 mm
EUR 595

13 mm Diameter Solid Titanium Tip

0-120-0011 13 mm
EUR 533

19 mm Diameter Tapped Titanium Tip

0-120-0012 19 mm
EUR 639

19 mm Diameter Solid Titanium Tip

0-120-0013 19 mm
EUR 570

25 mm Diameter Tapped Titanium Tip

0-120-0014 25 mm
EUR 682

25 mm Diameter Solid Titanium Tip

0-120-0015 25 mm
EUR 614

Flat Replaceable Tips 13 mm Diameter Flat Titanium Tip

0-120-0016 13 mm
EUR 86
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 19 mm Diameter Flat Titanium Tip

0-120-0017 19 mm
EUR 92
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Flat Replaceable Tips 25 mm Diameter Flat Titanium Tip

0-120-0018 25 mm
EUR 100
Description: use with corresponding Tapped Tips and Tapped Extender Tips

Titanium Cup Tip, 250 ml

0-120-0019 250 ml
EUR 1377
Description: includes Interface Washers

Microtube Tray, 8 Position (for 250 ml Cup Tip)

0-120-0021 each
EUR 113
Description: includes Interface Washers

Continuous Flow Chamber

0-120-0026 each
EUR 774
Description: includes Interface Washers

Interface Washers 1.5” Diameter, 5/Pkg

0-120-003 1.5'' Diameter
EUR 31

13 mm Diameter Solid Titanium Extender Tip

0-120-0032 13 mm
EUR 301

13 mm Diameter Tapped Titanium Extender Tip

0-120-0033 13 mm
EUR 362

19 mm Diameter Solid Titanium Extender Tip

0-120-0034 19 mm
EUR 315

19 mm Diameter Tapped Titanium Extender Tip

0-120-0035 19 mm
EUR 375

25 mm Diameter Solid Titanium Extender Tip

0-120-0036 25 mm
EUR 328

25 mm Diameter Tapped Titanium Extender Tip

0-120-0037 25 mm
EUR 389

KoldPod, 1.5ml Micro Tube

0-120-0038 1.5 ml
EUR 152
Description: Thermo conductive tube pods

KoldPod, 15ml Conical Tube

0-120-0039 15 ml
EUR 275
Description: Thermo conductive tube pods

KoldPod, 50ml Conical Tube

0-120-0040 50 ml
EUR 290
Description: Thermo conductive tube pods

Model 150 V/T Ultrasonic Homogenizer

0-121-0002 210-240V/50-60Hz
EUR 2920
Description: Delivers up to 150 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample processing processing.

Model 300 V/T Ultrasonic Homogenizer

0-122-0002 210-240V/50-60Hz
EUR 3520
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip. The Timer and Duty Cycle function increase preciosion in sample.

SONABOZ Sound Abating Chamber

0-125-0001 each
EUR 1020
Description: Reduces cavitational sound emitted during processing.

Model 3000 Ultrasonic Homogenizer

0-127-0002 210-240V/50-60Hz
EUR 4120
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip and includes an intergrated Sound Abating Chmaber to reduce cavitational sound emitted during processing. The Timer and Duty Cycle function increase preciosion in sample.

Model 3000MP Ultrasonic Homogenizer

0-128-0002 210-240V/50-60Hz
EUR 4720
Description: Delivers up to 300 Watts of ultrasonic power to the Titanium Tip with preciosion control from a microprocessor and a graphical user interface displayed on a large (145 mm) LCD display. The integrated Sound Abating Chamber reduces cavitational sound emitted during processing.

OMNICON® Zone Reader, 210-240V/50-60Hz

0-131-0002 210-240V/50-60Hz
EUR 35200
Description: Designed to Perform multi-plate Assays on round 90/100mm Petri Dishes. The integrated LED illumination system provides transmitted light for brightfield and darkfield illumination of transparent media.

OMNI-Noculator Peni Cylinder Filler, 210-240V/50-60Hz

0-134-0002 210-240V/50-60Hz
EUR 32200
Description: A robotic liquid handling system designed to dispense Peni Cylinders and fill Peni Cylinders with the corresponding antibiotic liquid sample.

Peni Cylinder Dispenser with Manual Hopper

0-144-0002 each
EUR 5406
Description: Dispenser can be configured to dispense 4 or 6 Peni Cylinders onto a petri dish.

Peni Cylinder Dispenser with Motorized Hopper, 100-240V/50-60Hz

0-144-0003 100-240V/50-60Hz
EUR 6254
Description: The motorized hopper can be configured to dispense 4 or 6 Peni Cylinders onto a petri Dispenser can be disassembled for disinfection.

Stainless Steel Peni Cylinder with Flat Face

0-144-0005 6mm I.D. x 8mm O.D. x 10mm Long
EUR 399
Description: sold in packages of 100 pieces

Stainless Steel Peni Cylinder with Chamfered Face

0-144-0006 6mm I.D. x 8mm O.D. x 10mm Long
EUR 412
Description: sold in packages of 100 pieces

Custom development of ELISAs for other species or antibody isotypes not listed in the catalog. Custom testing of samples for IgG/IgM/IgA or total (IgG+IgM+IgA)

000-CUS Custom
EUR 602

Alpha-Bungarotoxin, CF®405S, 500 ug

00002 1UG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s

00002 500uG
EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug

00002-1 EA
EUR 527

Alpha-Bungarotoxin, CF®405S 100ug

00002-100ug 100uG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

00003-1 EA
EUR 527

Alpha-Bungarotoxin, CF®680R 100ug

9-00003
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

00004-1 EA
EUR 527

Alpha-Bungarotoxin, CF®640R 100ug

9-00004
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

00005-1 EA
EUR 527

Alpha-Bungarotoxin CF®488A 100ug

9-00005
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

00006-1 EA
EUR 527

Alpha-Bungarotoxin, CF®568 100ug

9-00006
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

00007-1 EA
EUR 527

Alpha-Bungarotoxin CF®594 100ug

9-00007
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

00009-1 EA
EUR 527

Alpha-Bungarotoxin, CF®633 100ug

9-00009
  • Ask for price
  • Ask for price
  • 500uG
  • 100uG
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1 1MG
EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1-1 EA
EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011 500uG
EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011-1 EA
EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012 500uG
EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012-1 EA
EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug

00013 10ST
EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug

00013-1 EA
EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014 10ST
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015 500uG
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015-1 EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016 10ST
EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016-1 EA
EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug

00017 500uG
EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug

00017-1 EA
EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug

00018-1 EA
EUR 527

Alpha-Bungarotoxin, CF®555 100ug

9-00018
  • Ask for price
  • Ask for price
  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®

00019-100 100g
EUR 91
Description: 79-06-1

Acrylamide, Chemzymes Ultra Pure®

00019-500 500g
EUR 241
Description: 79-06-1

Biotin-cAMP, 1 mg

00020 1MG
EUR 298
Description: N/A

Biotin-cAMP, 1 mg

00020-1 20ST
EUR 298
Description: N/A

Biotin-cAMP, 50 ug

00020-1-1 EA
EUR 414

Biotin-cGMP, 1 mg

00021 1MG
EUR 331
Description: N/A

Biotin-cGMP, 1 mg

00021-1 20ST
EUR 331
Description: N/A

Biotin-cGMP, 20x50 ug

00021-1-1 EA
EUR 447

Cyanine 644-cAMP, 1 mg

00022 1MG
EUR 496
Description: N/A

Cyanine 644-cAMP, 1 mg

00022-1 20ST
EUR 496
Description: N/A

Cyanine 644-cAMP, 20x50 ug

00022-1-1 EA
EUR 647

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023 1MG
EUR 285
Description: N/A

Fluorescein Methotrexate, Triammonium Salt, 1 mg

00023-1 EA
EUR 285

Staurosporine

00025 100uG
EUR 100
Description: N/A

Staurosporine

00025-1 EA
EUR 100

Alpha-Bungarotoxin, CF®543, 500 ug

00026 500uG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®543, 500 ug

00026-1 EA
EUR 527

Alpha-Bungarotoxin, CF®543, 100 ug

00026-100ug 1UG
EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Rhodamine Phalloidin 300U

00027 300
EUR 364
Description: N/A

Rhodamine Phalloidin 300U

00027-1 EA
EUR 364

Biotin-XX-Phalloidin

00028 100U
EUR 466
Description: N/A

Biotin-XX-Phalloidin

00028-1 EA
EUR 466

Fluorescein-Phalloidin

00030 300U
EUR 364
Description: N/A

Fluorescein-Phalloidin

00030-1 EA
EUR 364

Rhodamine 110 Phalloidin

00032 300ST
EUR 364
Description: N/A

Rhodamine 110 Phalloidin

00032-1 EA
EUR 364

Sulforhodamine 101 (Texas Red®) Phalloidin

00033 300EU
EUR 364
Description: N/A

Sulforhodamine 101 (Texas Red®) Phalloidin

00033-1 EA
EUR 364

Phalloidin, CF®405M

00034 300U
EUR 482
Description: N/A

Phalloidin, CF®405M

00034-1 EA
EUR 482

Phalloidin, CF®405M

00034-T 50U
EUR 101
Description: N/A

Phalloidin, CF®405M

00034-T-1 EA
EUR 101

CF®488A-cAMP

00036 100ug
EUR 136
Description: N/A

CF®488A-cAMP

00036-1 EA
EUR 136

CF®640R-cAMP

00037 100ug
EUR 136
Description: N/A

CF®640R-cAMP

00037-1 EA
EUR 136

Phalloidin, CF555

00040 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF®647, 300 U

00041 300U
EUR 482
Description: N/A

Phalloidin, CF®647, 300 U

00041-1 EA
EUR 482

Phalloidin, CF®647, 50 U

00041-T 50U
EUR 101
Description: N/A

Phalloidin, CF®647, 50 U

00041-T-1 EA
EUR 101

Phalloidin, CF®488A, 300 U

00042 300U
EUR 482
Description: N/A

Phalloidin, CF®488A, 300 U

00042-1 EA
EUR 482

Phalloidin, CF®488A, 50 U

00042-T 50U
EUR 101
Description: N/A

Phalloidin, CF®488A, 50 U

00042-T-1 EA
EUR 101

Phalloidin, CF®543, 300 U

00043 300U
EUR 482
Description: N/A

Phalloidin, CF®543, 300 U

00043-1 EA
EUR 482

Phalloidin, CF®543, 50 U

00043-T 50U
EUR 101
Description: N/A

Phalloidin, CF®543, 50 U

00043-T-1 EA
EUR 101

Phalloidin, CF®568, 300 U

00044 300U
EUR 482
Description: N/A

Phalloidin, CF®568, 300 U

00044-1 EA
EUR 482

Phalloidin, CF®568, 50 U

00044-T 50U
EUR 101
Description: N/A

Phalloidin, CF®568, 50 U

00044-T-1 EA
EUR 101

Phalloidin, CF®594, 300 U

00045 300U
EUR 482
Description: N/A

Phalloidin, CF®594, 300 U

00045-1 EA
EUR 482

Phalloidin, CF®594, 50 U

00045-T 50U
EUR 101
Description: N/A

Phalloidin, CF®594, 50 U

00045-T-1 EA
EUR 101

Phalloidin, CF®633, 300 U

00046 300U
EUR 482
Description: N/A

Phalloidin, CF®633, 300 U

00046-1 EA
EUR 482

Phalloidin, CF®633, 50 U

00046-T 50U
EUR 101
Description: N/A

Phalloidin, CF®633, 50 U

00046-T-1 EA
EUR 101

Phalloidin, CF®660R, 300 U

00047 300U
EUR 482
Description: N/A

Phalloidin, CF®660R, 300 U

00047-1 EA
EUR 482

Phalloidin, CF®660R, 50 U

00047-T 50U
EUR 101
Description: N/A

Phalloidin, CF®660R, 50 U

00047-T-1 EA
EUR 101

All of the steps of the experiment had been carried out in duplicate. After intervals of 12, 24, and 48 hours, LIF decreased each the expression and presentation of the NKG2D receptor on NK cells. The outcomes counsel that this cytokine has a direct modulating exercise on the physique’s immune response via suppression of NKG2D receptor expression and presentation on NK cells.

Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell.

Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell.

NK cells are lymphocytes with antitumor properties and may straight lyse tumor cells in a non-MHC-restricted method. However, the tumor microenvironment impacts the immune perform of NK cells, which leads to immune evasion. This could also be associated to the pathogenesis of some ailments.

Therefore, nice efforts have been made to enhance the immunotherapy impact of pure killer cells. NK cells from completely different sources can meet completely different medical wants, so as to decrease the inhibition of NK cells and maximize the response potential of NK cells, for instance, modification of NK cells can enhance the quantity of NK cells in tumor goal space, change the path of NK cells, and enhance their concentrating on potential to malignant cells.

Checkpoint blocking can also be a promising technique for NK cells to kill tumor cells. Combination remedy is one other technique for enhancing antitumor potential, particularly together with oncolytic viruses and nanomaterials. In this paper, the mechanisms affecting the exercise of NK cells have been reviewed, and the therapeutic potential of completely different primary NK cell methods in tumor remedy was centered on.

The major methods for enhancing the immune perform of NK cells have been described, and a few new methods have been proposed.

Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell.
Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell.

XRP44X Enhances the Cytotoxic Activity of Natural Killer Cells by Activating the c-JUN N-Terminal Kinase Signaling Pathway.

Natural killer (NK) cells are innate lymphocytes that play a vital function in stopping most cancers improvement by performing immune surveillance to eradicate irregular cells. Since ex vivo expanded NK cells have cytotoxic exercise against numerous cancers, together with breast cancers, their medical potential as immune-oncogenic therapeutics has been broadly investigated.

Here, we report that the pyrazole chemical XRP44X, an inhibitor of Ras/ERK activation of ELK3, stimulates NK-92MI cells to improve cytotoxic exercise against breast most cancers cells. Under XRP44X stimulation, NK cells didn’t present notable apoptosis or impaired cell cycle development.

We demonstrated that XRP44X enhanced interferon gamma expression in NK-92MI cells. We additionally elucidated that potentiation of the cytotoxic exercise of NK-92MI cells by XRP44X is induced by activation of the c-JUN N-terminal kinase (JNK) signaling pathway. Our knowledge present perception into the analysis of XRP44X as an immune stimulant and that XRP44X is a possible candidate compound for the therapeutic improvement of NK cells.