Natural killer (NK) cells are innate effectors armed with cytotoxic and cytokine-secreting capacities whose spontaneous antitumor exercise is vital to quite a few immunotherapeutic methods. However, present mouse fashions fail to reflect the in depth immune system variation that exists in the human inhabitants which can impression on NK cell-based therapies. We carried out a complete profiling of NK cells in the Collaborative Cross (CC), a set of novel recombinant inbred mouse strains whose genetic diversity matches that of people, thereby offering a novel and extremely various small animal mannequin for the research of immune variation.
We exhibit that NK cells from CC strains displayed a breadth of phenotypic and useful variation reminiscent of that reported for people on the subject of cell numbers, key marker expression, and useful capacities. We took benefit of the huge genetic diversity of the CC and recognized 9 genomic loci via quantitative trait locus mapping driving these phenotypic variations. SNP haplotype patterns and variant impact analyses recognized candidate genes related to lung NK cell numbers, frequencies of CD94+ NK cells, and expression ranges of NKp46.
Thus, we exhibit that the CC represents an impressive useful resource to check NK cell diversity and its regulation by host genetics.Natural killer (NK) cells, as a possible supply for off-the-shelf cell remedy, assault tumor cells with low danger of extreme cytokine launch syndrome (CRS) or graft-versus-host illness (GvHD). Fcγ receptor IIIA, also referred to as CD16, additional confers NK cells with antibody-dependent cell-mediated cytotoxicity (ADCC), one mechanism of motion of antibody-based immunotherapy.
Here, we set up a novel human NK cell line, oNK-1, endogenously expressing CD16 together with excessive ranges of NK activation markers and low ranges of NK inhibitory markers. The long-term growth and CD16 expression of oNK-1 cells had been demonstrated. Furthermore, oNK-1 cells elicit superior cytotoxicity in opposition to most cancers cells than major NK cells. In conclusion, this research means that endogenous CD16-expressing oNK-1 has the potential to develop an efficient NK-based remedy.
Core 2 β1,6-N-acetylglucosaminyltransferases speed up the escape of choriocarcinoma from natural killer cell immunity
Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and incorporates a core2 O-glycan shaped by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT). Choriocarcinoma is taken into account immunogenic as it’s gestational and incorporates paternal chromosomal elements. Here we examined the perform of C2GnT in the evasion of choriocarcinoma cells from natural killer (NK) cell-mediating killing. We decided that C2GnT is very expressed in malignant gestational trophoblastic neoplasms.
C2GnT KO downregulates core2 O-glycan expression in choriocarcinoma cells, that are extra effectively killed by NK cells than control cells. C2GnT KO cell containing tumor necrosis factor-related apoptosis inducing ligand have decrease viability than control cells. Additionally, poly-N-acetyllactosamine in core2 branched oligosaccharides on MHC class I-related chain A (MICA) and mucin1 (MUC1) is considerably decreased in C2GnT KO cells. Meanwhile, the cumulative survival price of nude mice inoculated with C2GnT KO tumors was greater than that of the control group. These findings counsel that choriocarcinoma cells might escape NK cell-mediated killing by way of glycosylation of MICA and MUC1.
Invariant Natural Killer T (iNKT) cells are innate-like T Lymphocytes expressing a conserved semi-invariant T cell receptor (TCR) particular for self or microbial lipid antigens introduced by the non-polymorphic MHC class I-related molecule CD1d. Preclinical and medical research assist a task for iNKT cells in most cancers, autoimmunity and infectious ailments. iNKT cells are very conserved all through species and their investigation has been facilitated by mouse fashions, together with CD1d-deficient or iNKT-deficient mice, and the chance to unequivocally detect them in mice and males with CD1d tetramers or mAbs particular for the semi-invariant TCR.
However, iNKT cells are uncommon they usually must be expanded to succeed in manageable numbers for any research. Because the era of major mouse iNKT cell line in vitro has confirmed troublesome, now we have arrange a sturdy protocol to purify and increase splenic iNKT cells from the iVα14-Jα18 transgenic mice (iVα14Tg), in which iNKT cells are 30 instances extra frequent. We present right here that major splenic iVα14Tg iNKT cells could be enriched via an immunomagnetic separation course of, yielding about 95-98% pure iNKT cells.
Leukemia Inhibitory Factor Suppresses NKG2D mRNA Expression and Presentation on Human Natural Killer Cells
Leukemia inhibitory issue (LIF) is a multi-functional cytokine secreted from cells corresponding to lymphocytes and hepatocytes. This research aimed to judge the impact of LIF on natural killer group 2 member D (NKG2D) receptors’ expression and presentation on natural killer (NK) cells. For this function, peripheral blood mononuclear cells taken from four younger male wholesome blood donors had been remoted and the impact of LIF (25 ng/mL) after 12, 24, and 48 hours of incubation, on NKG2D receptors expression and presentation was investigated utilizing circulation cytometry and real-time-polymerase chain response (PCR).
Alpha-bungarotoxin, CF680r |
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| 9-00003 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF640r |
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| 9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF640r |
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| 9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin |
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| 00010-1 | Biotium | 1MG | EUR 168 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Fluorescein-Alpha-bungarotoxin |
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| 00011 | Biotium | 500uG | EUR 367 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Tetramethylrhodamine-Alpha-bungarotoxin |
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| 00012 | Biotium | 500uG | EUR 383 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Fluorescein-alpha-bungarotoxin: (10x50ug) |
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| 00013 | Biotium | 10ST | EUR 417 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug) |
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| 00014 | Biotium | 10ST | EUR 466 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug) |
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| 00015 | Biotium | 500uG | EUR 466 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug) |
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| 00016 | Biotium | 10ST | EUR 523 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Biotin-xx-a-bungarotoxin |
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| 00017 | Biotium | 500uG | EUR 433 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 100ug |
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Biotin-cAMP, diisopropylethylammonium salt: |
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| 00020 | Biotium | 1MG | EUR 314 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Biotin-cAMP, diisopropylethylammonium salt: (20x50ug) |
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| 00020-1 | Biotium | 20ST | EUR 418 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Biotin-cGMP, diisopropylethylammonium salt: |
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| 00021 | Biotium | 1MG | EUR 344 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Biotin-cGMP, diisopropylethylammonium salt: (20x50ug) |
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| 00021-1 | Biotium | 20ST | EUR 448 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Cyanine 644-cAMP: |
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| 00022 | Biotium | 1MG | EUR 491 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Cyanine 644-cAMP: (20x50ug) |
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| 00022-1 | Biotium | 20ST | EUR 625 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Fluorescein Methotrexate, triammonium salt: |
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| 00023 | Biotium | 1MG | EUR 281 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Staurosporine |
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| 00025 | Biotium | 100uG | EUR 139 |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF543 |
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| 00026 | Biotium | 500uG | EUR 494 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Rhodamine phalloidin 300u |
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| 00027 | Biotium | 300 | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300 |
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Biotin-xx-phalloidin |
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| 00028 | Biotium | 100U | EUR 428 |
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Description: Minimum order quantity: 1 unit of 100U |
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Fluorescein-phalloidin |
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| 00030 | Biotium | 300U | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300U |
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Rhodamine 110 phalloidin |
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| 00032 | Biotium | 300ST | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300ST |
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Sulforhodamine 101 (Texas-Red) Phalloidin |
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| 00033 | Biotium | 300EU | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300EU |
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Phalloidin, CF405M |
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| 00034 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF405M |
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| 00034-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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CF488A-cAMP |
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| 00036 | Biotium | 100ug | EUR 172 |
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Description: Minimum order quantity: 1 unit of 100ug |
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CF640R-cAMP |
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| 00037 | Biotium | 100ug | EUR 172 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Phalloidin, CF555 |
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| 00040 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF555 |
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| 00040-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF647 |
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| 00041 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF647 |
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| 00041-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF488A |
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| 00042 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF488A |
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| 00042-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF543 |
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| 00043 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF543 |
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| 00043-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF568 |
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| 00044 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF568 |
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| 00044-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF594 |
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| 00045 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF594 |
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| 00045-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF633 |
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| 00046 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF633 |
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| 00046-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF660R |
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| 00047 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660R |
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| 00047-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF680R |
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| 00048 | Biotium | 300U | EUR 466 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680R |
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| 00048-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF350 |
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| 00049 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF350 |
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| 00049-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF640R |
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| 00050 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF640R |
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| 00050-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF532 |
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| 00051 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF532 |
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| 00051-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF660C |
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| 00052 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660C |
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| 00052-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF680 |
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| 00053 | Biotium | 300U | EUR 466 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680 |
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| 00053-T | Biotium | 50U | EUR 147 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF430 |
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| 00054 | Biotium | 300U | EUR 449 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF430 |
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| 00054-T | Biotium | 50U | EUR 139 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF440 |
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| 00055 | Biotium | 300U | EUR 449 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF440 |
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| 00055-T | Biotium | 50U | EUR 139 |
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Description: Minimum order quantity: 1 unit of 50U |
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Cholera Toxin Subunit B, CF488A conjugate |
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| 00070 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF568 conjugate |
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| 00071 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF594 conjugate |
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| 00072 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF640R conjugate |
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| 00073 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF532 conjugate |
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| 00074 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF543 conjugate |
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| 00075 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF620R conjugate |
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| 00076 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF633 conjugate |
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| 00077 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF660R conjugate |
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| 00078 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF680R conjugate |
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| 00079 | Biotium | 100ug | EUR 282 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Human Transferrin, CF488A conjugate |
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| 00081 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF543 conjugate |
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| 00082 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF568 conjugate |
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| 00083 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF594 conjugate |
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| 00084 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF640R conjugate |
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| 00085 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF680R conjugate |
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| 00086 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF750 conjugate |
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| 00087 | Biotium | 1mg | EUR 155 |
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Description: Minimum order quantity: 1 unit of 1mg |
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HIV-1 tat recombinant antigen |
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| 00110-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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HIV-1 tat recombinant antigen |
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| 00110-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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HIV-1 nef recombinant antigen |
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| 00112-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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HIV-1 nef recombinant antigen |
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| 00112-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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HIV-1 env gp41 recombinant antigen |
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| 00113-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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HIV-1 env gp41 recombinant antigen |
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| 00113-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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HCV core recombinant antigen |
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| 00115-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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HCV core recombinant antigen |
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| 00115-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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HCV NS4 recombinant antigen NS4a+b |
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| 00116-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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HCV NS4 recombinant antigen NS4a+b |
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| 00116-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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HCV NS4 recombinant antigen NS4a+b, Biotin |
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| 00116-V-B-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
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HCV NS4 recombinant antigen NS4a+b, Biotin |
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| 00116-V-B-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
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HCV NS4 recombinant antigen NS4a+b, FITC |
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| 00116-V-F-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
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HCV NS4 recombinant antigen NS4a+b, FITC |
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| 00116-V-F-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
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HCV NS4 recombinant antigen NS4a+b, Rhodamine |
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| 00116-V-R-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
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HCV NS4 recombinant antigen NS4a+b, Rhodamine |
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| 00116-V-R-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
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HCV NS3 recombinant antigen |
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| 00117-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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HCV NS3 recombinant antigen |
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| 00117-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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HBV core recombinant antigen |
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| 00120-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
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HBV core recombinant antigen |
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| 00120-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
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HBV core recombinant antigen, Delta |
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| 00121-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
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HBV core recombinant antigen, Delta |
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| 00121-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
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HBV surface recombinant antigen HBsAg |
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| 00122-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
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HBV surface recombinant antigen HBsAg |
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| 00122-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
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HBV surface recombinant antigen HBsAg antigen |
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| 00123-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
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HBV surface recombinant antigen HBsAg antigen |
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| 00123-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
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HBV surface recombinant antigen HBsAg antigen |
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| 00124-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
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HBV surface recombinant antigen HBsAg antigen |
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| 00124-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
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HEV (Birma) ORF2 recombinant antigen |
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| 00131-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
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HEV (Birma) ORF2 recombinant antigen |
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| 00131-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
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HEV (Birma) ORF2 recombinant antigen |
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| 00132-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
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HEV (Birma) ORF2 recombinant antigen |
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| 00132-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
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AA 403-461 HEV Birma ORF2 Recombinant Antigen |
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| 00133-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
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AA 403-461 HEV Birma ORF2 Recombinant Antigen |
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| 00133-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
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T, Pallidum recombinant antigen p15 |
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| 00141-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: T. Pallidum recombinant antigen p15 (full length) |
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T, Pallidum recombinant antigen p15 |
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| 00141-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: T. Pallidum recombinant antigen p15 (full length) |
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T, Pallidum recombinant antigen p17 |
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| 00142-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: T. Pallidum recombinant antigen p17 (full length) |
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T, Pallidum recombinant antigen p17 |
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| 00142-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: T. Pallidum recombinant antigen p17 (full length) |
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T, Pallidum recombinant antigen p45 |
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| 00143-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: T. Pallidum recombinant antigen p45 (full length) |
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T, Pallidum recombinant antigen p45 |
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| 00143-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: T. Pallidum recombinant antigen p45 (full length) |
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T, pallidum recombinant antigen TmpA |
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| 00144-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: T. Pallidum recombinant antigen TmpA (full length) |
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T, pallidum recombinant antigen TmpA |
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| 00144-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: T. Pallidum recombinant antigen TmpA (full length) |
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HCV core 2-119aa recombinant antigen |
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| 00150-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
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HCV core 2-119aa recombinant antigen |
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| 00150-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
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All of the steps of the experiment had been carried out in duplicate. After intervals of 12, 24, and 48 hours, LIF decreased each the expression and presentation of the NKG2D receptor on NK cells. The outcomes counsel that this cytokine has a direct modulating exercise on the physique’s immune response via suppression of NKG2D receptor expression and presentation on NK cells.