CD56bright Natural Killer Cells: A Possible Biomarker of Different Treatments in Multiple Sclerosis.

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system, which leads, in many cases, to irreversible disability. More than 15 disease-modifying treatments (DMTs) are available for the treatment of MS. Clinical activity or activity at magnetic resonance imaging (MRI) are now used to assess the efficacy of DMTs, but are negative prognostic factors per se.

Therefore, a biomarker permitting us to identify patients who respond to treatment before they develop clinical/radiological signs of MS activity would be of high importance. The number of circulating CD56bright natural killer (NK) cells may be such a biomarker. CD56bright NK cells are a regulatory immune population belonging to the innate immune system.

The number of CD56bright NK cells increases upon treatment with interferon-beta, alemtuzumab, dimethyl fumarate, after autologous hematopoietic stem cell transplantation, and is higher in those who respond to fingolimod. In some cases, an increased number of CD56bright NK cells is associated with an increase in their regulatory function.

2',3',5'-triacetyl-5-Azacytidine

C4119-5 5 mg
EUR 118.00
Description: 2',3',5'-triacetyl-5-Azacytidine (TAC) is the lead prodrug form of 5-azacytidine which may be rapidly absorbed after oral administration [1]. 5-Azacytidine is an inhibitor of DNA methyltransferase [2].

GNF-5

B1329-5
EUR 142.00

5-ROX

B8212-5 5 mg
EUR 195.00

Necrostatin-5

1865-5
EUR 126.00

Aftin-5

2575-5
EUR 457.00

CHD-5

2693-5
EUR 153.00

Histatin 5

5-01307 4 x 1mg Ask for price

5-Iodotubercidin

A3125-5 5 mg
EUR 168.00
Description: 5-Iodotubercidin (Itu) is a purine derivative and hence an inhibitor of adenosine kinase with an IC50 value of 26 nM [1]. Adenosine kinase is important in regulating the intracellular and extracellular concentrations of adenosine and hence diverse physiological actions of adenosine [2].

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

A1036-5 5 mg
EUR 102.00
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5),(C30H50N8O7), a peptide with the sequence NH2-Ser-Phe-Leu-Leu-Arg-COOH, MW= 634.76. coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response.

5'-deoxy Thymidine

C4692-5 5 mg
EUR 180.00
Description: 5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines.

Teicoplanin A2-5

C4938-5 5 mg
EUR 1157.00
Description: Teicoplanin A2-5, derived from Actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria.

5-fluoro 203

C4114-5 5 mg
EUR 154.00
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450.

W-5 hydrochloride

B6277-5 5 mg
EUR 116.00

5-Nonyloxytryptamine oxalate

B6496-5 5 mg
EUR 154.00

2',5'-Dideoxyadenosine

2770-5
EUR 240.00

ACTH(5-10)

5-00605 4 x 5mg Ask for price

Angiotensin (1-5)

5-00676 4 x 5mg Ask for price

Bradykinin (1-5)

5-00852 4 x 5mg Ask for price

TRAP-5 amide

5-02019 4 x 5mg Ask for price

[Cit5]-TRAP-5

5-00062 4 x 5mg Ask for price

A-VI-5

5-00524 4 x 5mg Ask for price

5-Formylcytosine (5-fC) ELISA Kit

MET-5102-5 5 x 96 assays
EUR 2283.00

5-Carboxylcytosine (5-caC) ELISA Kit

MET-5103-5 5 x 96 assays
EUR 2283.00

5-Nitroso-8-quinolinol

B2825-5
EUR 109.00

5'-(N-Cyclopropyl)carboxamidoadenosine

C4645-5 5 mg
EUR 128.00

2',5'-dideoxy Adenosine

C3993-5 5 mg
EUR 189.00
Description: 2',5'-dideoxy Adenosine, a nucleoside analog, is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase [1]. Adenylyl cyclase is an enzyme with key regulatory roles in almost all cells.

5-trans U-46619

C4261-5 5 mg
EUR 538.00
Description: 5-trans U-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of U-46619 [1]. U-46619 is a selective thromboxane A2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2].

Necrosis Inhibitor, Necrox-5

2229-5
EUR 615.00

Dok- 5 (263 - 275)

5-01048 4 x 5mg Ask for price

Secretin (5 - 27), porcine

5-01917 4 x 1mg Ask for price

SH2 Domain Ligand (5)

5-01929 4 x 5mg Ask for price

Boc-5-Ava-OH

5-04607 25g Ask for price

Boc-5-Ava-OH

5-04608 100g Ask for price

Fmoc-5-Ava-OH

5-04609 5g Ask for price

Fmoc-5-Ava-OH

5-04610 25g Ask for price

FAM azide, 5- isomer

A8117-5 5 mg
EUR 166.00
Description: FAM azide for Click chemistry labeling. FAM remains one of the most popular fluorescent lablels for various application. Most instruments capable of fluorescence detection, ranging from plate readers to fluorescence microscopes, are able to work in FAM channel.

ROX azide, 5- isomer

A8126-5 5 mg
EUR 583.00
Description: ROX (rhodamine-X) azide, solid material, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. ROX is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield.Pure 5-isomer.

TAMRA azide, 5- isomer

A8129-5 5 mg
EUR 583.00
Description: TAMRA (TMR, tetramethylrhodamine) azide, solid compound, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. Pure 5-isomer.TAMRA is often used as FRET acceptor for FAM fluorophore.

AICA riboside, 5'-phosphate

9416-5
EUR 153.00

Individual Reaction Mix 5

G065-5 200 reactions
EUR 167.00

3,3',5'-Triiodo-L-thyronine

B2017-5
EUR 229.00

Helioxanthin derivative 5-4-2

B4700-5 5 mg
EUR 683.00
Description: Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 ?M, 0.29 ?M and 0.16 ?M, respectively [1].

3,3',5'-Triiodo-L-thyronine

C5014-5 5 mg
EUR 134.00
Description: 3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TR? and TR? antagonist [1].

5?-dihydro-11-keto Testosterone

C4317-5 5 mg
EUR 586.00
Description: 5?-dihydro-11-keto Testosterone (11KDHT) is a full androgen receptor agonist comparable to dihydrotestosterone (DHT) [1][2][3].

2'-O-Methylpseudouridine-5'-Triphosphate

B7993-.5 5x100 µl (100 mM)
EUR 14023.00

2'-Fluoro-thymidine-5'-Triphosphate

B8035-.5 5x100 µl (100 mM)
EUR 2059.00

2-Methyl-5-hydroxytryptamine hydrochloride

2768-5
EUR 185.00

Angiotensin I/II (5-8)

5-00684 4 x 5mg Ask for price

Cholecystokinin Octapeptide (1-5) (desulfated)

5-00970 4 x 5mg Ask for price

HIV-gp41-Antigenic Peptide 5

5-01331 4 x 1mg Ask for price

Angiotensin 1/2 (1-5)

A1047-5 5 mg
EUR 119.00
Description: Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.Angiotensin I is formed by the action ofreninonangiotensinogen, an ?-2-globulin with 12 amino acids.

Angiotensin 1/2 (5-7)

A1049-5 5 mg
EUR 119.00
Description: Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

[Pyr5]-Substance P (5-11)

5-00288 4 x 5mg Ask for price

[Trp3, Arg5]-Ghrelin (1-5)

5-00313 4 x 5mg Ask for price

beta-Casomorphin (1-5) (bovine)

5-00475 4 x 5mg Ask for price

Fmoc-Trp(5-OH)-OH

5-06939 5g Ask for price

Fmoc-Trp(5-OH)-OH

5-06940 25g Ask for price

Magnetic Beads (DNA) 5 mL

P920-5 NULL
EUR NULL

pLenti-CLDN1 shRNA-5 Plasmid

PVTBAV04867-5 2 ug
EUR 356.00

3-bromo-5-phenyl Salicylic Acid

C4516-5 5 mg
EUR 370.00
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor.

5-bromo-3-phenyl Salicylic Acid

C4610-5 5 mg
EUR 319.00

5-(N,N-dimethyl)-Amiloride (hydrochloride)

C3505-5 5 mg
EUR 180.00
Description: 5-(N, N-dimethyl)-Amiloride (hydrochloride), a derivative of amiloride, is an inhibitor of NHE1, NHE2, and NHE3. The Na+/H+ exchanger (NHE) is a protein that has been involved in intracellular pH homeostasis of many mammalian cell types.

2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate

B7959-.5 5x100 µl (100 mM)
EUR 2059.00

2'-Fluoro-2'-deoxycytidine-5'-Triphosphate

B7961-.5 5x100 µl (100 mM)
EUR 2059.00

2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate

B7962-.5 5x100 µl (100 mM)
EUR 2059.00

2'-Fluoro-2'-deoxyuridine-5'-Triphosphate

B7963-.5 5x100 µl (100 mM)
EUR 2059.00

cAMP Dependent PK Inhibitor (5-24)

5-00922 4 x 1mg Ask for price

Kinase Domain of Insulin Receptor (5)

5-01429 4 x 1mg Ask for price

Fmoc-D-Trp(5-Br)-OH

5-04217 1g Ask for price

Fmoc-D-Trp(5-Br)-OH

5-04218 5g Ask for price

Fmoc-D-Trp(5-Cl)-OH

5-04223 1g Ask for price

Fmoc-D-Trp(5-Cl)-OH

5-04224 5g Ask for price

Fmoc-D-Trp(5-F)-OH

5-04227 1g Ask for price

Fmoc-D-Trp(5-F)-OH

5-04228 5g Ask for price

Ac-DL-Trp(5-Br)-OH·DCHA

5-04229 1g Ask for price

Ac-DL-Trp(5-Br)-OH·DCHA

5-04230 5g Ask for price

Ac-DL-Trp(5-Cl)-OH·DCHA

5-04231 1g Ask for price

Ac-DL-Trp(5-Cl)-OH·DCHA

5-04232 5g Ask for price

Fmoc-2-amino-5-Methoxybenzoic acid

5-04549 1g Ask for price

Fmoc-2-amino-5-Methoxybenzoic acid

5-04550 5g Ask for price

Fmoc-3-Ala(5-Thiazoyl)-OH

5-05361 1g Ask for price

Fmoc-3-Ala(5-Thiazoyl)-OH

5-05362 5g Ask for price

Beta-Sheet Breaker Peptide iA?5

A1005-5 5 mg
EUR 102.00
Description: Beta-Sheet Breaker Peptide iA?5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models.

7078D 5 PIPET 5ML STERILE STERILE

7078D-5 25/pk
EUR 217.00
Description: Disposable Pipets; Disposable Pipets, Serological, Misc

beta-Casomorphin (1-5) amide (bovine)

5-00476 4 x 5mg Ask for price

Nickel NTA Magnetic Agarose Bead (5%)

MagNTANi5-5 5ml suspension
EUR 174.00

CytoSelect Clonogenic Tumor Cell Isolation Kit (5 x 5 preps)

CBA-155-5 25 preps
EUR 3245.00
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis.

5-Hydroxytryptamine (5-HT) ELISA Kit

DL-5-HT-Ge-192 1 kit of 192 tests
EUR 1028.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 5-Hydroxytryptamine (5-HT)

5-Hydroxytryptamine (5-HT) ELISA Kit

DL-5-HT-Ge-48 1 kit of 48 tests
EUR 439.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 5-Hydroxytryptamine (5-HT)

5-Hydroxytryptamine (5-HT) ELISA Kit

DL-5-HT-Ge-96 1 kit of 96 tests
EUR 584.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 5-Hydroxytryptamine (5-HT)

5-Hydroxytryptamine (5-HT) ELISA Kit

DLR-5-HT-Ge-48T 48T
EUR 469.00
  • Should the 5-Hydroxytryptamine (5-HT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids.

5-Hydroxytryptamine (5-HT) ELISA Kit

DLR-5-HT-Ge-96T 96T
EUR 608.00
  • Should the 5-Hydroxytryptamine (5-HT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids.

S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

B2826-5
EUR 120.00

2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide

C4686-5 5 mg
EUR 232.00

DiagNano Silica-Coated Gold Nanoparticles, 5 nm

CG-5 10mL
EUR 719.00

Biotin-Kinase Domain of Insulin Receptor (5)

5-00799 4 x 1mg Ask for price

cAMP Dependent PK Inhibitor (5-22), amide

5-00921 4 x 1mg Ask for price

Substance P (5-11)/Hepta-Substance P

5-01979 4 x 5mg Ask for price

[D-Ala2]- beta-Casomorphin (1-5), bovine

5-00075 4 x 5mg Ask for price

[D-Pro2]-beta-Casomorphin (1-5) , bovine

5-00133 4 x 5mg Ask for price

beta-Endorphin (1-5) + (16-31), human

5-00488 4 x 1mg Ask for price

DiagNano Fluorophore Labeled Gold Nanoparticles, 5 nm

GFL-5 1 mL
EUR 1053.00

5-min. Genomic DNA Prep for PCR

P930-5 NULL
EUR NULL

[D-Ala2]- beta-Casomorphin (1-5) amide (bovine)

5-00074 4 x 5mg Ask for price

[D-Ala2, Met5]- ß-Casomorphin (1-5), bovine

5-00092 4 x 5mg Ask for price

[D-Pro2]-beta-Casomorphin (1-5) , bovine, amide

5-00134 4 x 5mg Ask for price

DiagNano Gold Nanoparticle Passive Conjugation Kit, 5 nm

GPK-5 1 kit
EUR 715.00

DiagNano Silica-Coated PEGylated Gold Nanoparticles, 5 nm

PG-5 10mL
EUR 719.00

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

DL-5-HIAA-Ge-192 1 kit of 192 tests
EUR 1305.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 5-Hydroxyindoleacetic Acid (5-HIAA)

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

DL-5-HIAA-Ge-48 1 kit of 48 tests
EUR 535.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 5-Hydroxyindoleacetic Acid (5-HIAA)

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

DL-5-HIAA-Ge-96 1 kit of 96 tests
EUR 722.00
Description: An ELISA kit based on the competitive inhibition method for detection and quantification of 5-Hydroxyindoleacetic Acid (5-HIAA)

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

DLR-5-HIAA-Ge-48T 48T
EUR 575.00
  • Should the 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids.

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit

DLR-5-HIAA-Ge-96T 96T
EUR 753.00
  • Should the 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids.

General 5-Hydroxytryptamine (5-HT) ELISA Kit

RDR-5-HT-Ge-48Tests 48 Tests
EUR 488.00

General 5-Hydroxytryptamine (5-HT) ELISA Kit

RDR-5-HT-Ge-96Tests 96 Tests
EUR 676.00

General 5-Hydroxytryptamine (5-HT) ELISA Kit

RD-5-HT-Ge-48Tests 48 Tests
EUR 467.00

General 5-Hydroxytryptamine (5-HT) ELISA Kit

RD-5-HT-Ge-96Tests 96 Tests
EUR 646.00

Checkit Pro C02 - 5 pack

CP-C02-5 5pack
EUR 207.00
Description: Pipette Checkit Pro model for 2uL pipettes. Pack of 5.

Checkit Pro C05 - 5 pack

CP-C05-5 5pack
EUR 198.00
Description: Pipette Checkit Pro model for 5uL pipettes. Pack of 5.

Checkit Pro C10 - 5 pack

CP-C10-5 5pack
EUR 198.00
Description: Pipette Checkit Pro model for 10uL pipettes. Pack of 5.

In the current review, we will evaluate the known effect on CD56bright NK cells of DMTs for MS, and will discuss their possible role as a biomarker for treatment response in MS.