Immune Cell Subtypes and Cytokines in Lung Tumor Microenvironment: Influence of COPD.

The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by T regulatory (Treg), naturalkiller (NK), and plasma cells, as well as interleukin (IL)-10 and interferon-gamma, may differ within tumors of LC patients with/without COPD.

Treg (anti-CD3 and anti-forkhead boxP3 antibodies), NK (anti-NCR1 antibody), IgG (anti-CD138-IgG antibody), IgA (anti-CD138-IgA antibody) using immunohistochemistry, and both IL-10 and interferon-gamma (ELISA) were quantified in tumor and non-tumor specimens (thoracotomy for lung tumor resection) from 33 LC-COPD patients and 20 LC-only patients.

Immune profile in tumor versus non-tumor specimens: Treg cell counts significantly increased in tumors of both LC and LC-COPD patients, while in tumors of the latter group, IgG-secreting plasma cells significantly decreased and IL-10 increased. No significant differences were seen in levels of NK cells, IgA-secreting cells, IgA/IgG, or interferon-gamma.

Necrostatin-5
1865-5
EUR 151.2

Aftin-5
2575-5
EUR 548.4

CHD-5
2693-5
EUR 183.6

5-Iodotubercidin
A3125-5 5 mg
EUR 201.6
Description: 5-Iodotubercidin (Itu) is a purine derivative and hence an inhibitor of adenosine kinase with an IC50 value of 26 nM [1]. Adenosine kinase is important in regulating the intracellular and extracellular concentrations of adenosine and hence diverse physiological actions of adenosine [2].

GNF-5
B1329-5
EUR 170.4

5-ROX
B8212-5 5 mg
EUR 234

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
A1036-5 5 mg
EUR 122.4
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5),(C30H50N8O7), a peptide with the sequence NH2-Ser-Phe-Leu-Leu-Arg-COOH, MW= 634.76. coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response.

5'-deoxy Thymidine
C4692-5 5 mg
EUR 216
Description: 5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines.

Teicoplanin A2-5
C4938-5 5 mg
EUR 1388.4
Description: Teicoplanin A2-5, derived from Actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria.

5-fluoro 203
C4114-5 5 mg
EUR 184.8
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450.

[Cit5]-TRAP-5
5-00062 4 x 5mg Ask for price

A-VI-5
5-00524 4 x 5mg Ask for price

ACTH(5-10)
5-00605 4 x 5mg Ask for price

Angiotensin (1-5)
5-00676 4 x 5mg Ask for price

Bradykinin (1-5)
5-00852 4 x 5mg Ask for price

TRAP-5 amide
5-02019 4 x 5mg Ask for price

2',5'-Dideoxyadenosine
2770-5
EUR 288

W-5 hydrochloride
B6277-5 5 mg
EUR 139.2

5-Nonyloxytryptamine oxalate
B6496-5 5 mg
EUR 184.8

5-Formylcytosine (5-fC) ELISA Kit
MET-5102-5 5 x 96 assays
EUR 2283

5-Carboxylcytosine (5-caC) ELISA Kit
MET-5103-5 5 x 96 assays
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5'-(N-Cyclopropyl)carboxamidoadenosine
C4645-5 5 mg
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5-trans U-46619
C4261-5 5 mg
EUR 645.6
Description: 5-trans U-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of U-46619 [1]. U-46619 is a selective thromboxane A2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2].

2',5'-dideoxy Adenosine
C3993-5 5 mg
EUR 226.8
Description: 2',5'-dideoxy Adenosine, a nucleoside analog, is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase [1]. Adenylyl cyclase is an enzyme with key regulatory roles in almost all cells.

Boc-5-Ava-OH
5-04607 25g Ask for price

Boc-5-Ava-OH
5-04608 100g Ask for price

Fmoc-5-Ava-OH
5-04609 5g Ask for price

Fmoc-5-Ava-OH
5-04610 25g Ask for price

Dok- 5 (263 - 275)
5-01048 4 x 5mg Ask for price

Secretin (5 - 27), porcine
5-01917 4 x 1mg Ask for price

SH2 Domain Ligand (5)
5-01929 4 x 5mg Ask for price

Necrosis Inhibitor, Necrox-5
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FAM azide, 5- isomer
A8117-5 5 mg
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Description: FAM azide for Click chemistry labeling. FAM remains one of the most popular fluorescent lablels for various application. Most instruments capable of fluorescence detection, ranging from plate readers to fluorescence microscopes, are able to work in FAM channel.

ROX azide, 5- isomer
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Description: ROX (rhodamine-X) azide, solid material, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. ROX is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield.Pure 5-isomer.

TAMRA azide, 5- isomer
A8129-5 5 mg
EUR 699.6
Description: TAMRA (TMR, tetramethylrhodamine) azide, solid compound, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. Pure 5-isomer.TAMRA is often used as FRET acceptor for FAM fluorophore.

AICA riboside, 5'-phosphate
9416-5
EUR 183.6

5-Nitroso-8-quinolinol
B2825-5
EUR 130.8

Individual Reaction Mix 5
G065-5 200 reactions
EUR 200.4

Magnetic Beads (DNA) 5 mL
P920-5 - Ask for price

3,3',5'-Triiodo-L-thyronine
C5014-5 5 mg
EUR 160.8
Description: 3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TR? and TR? antagonist [1].

5?-dihydro-11-keto Testosterone
C4317-5 5 mg
EUR 703.2
Description: 5?-dihydro-11-keto Testosterone (11KDHT) is a full androgen receptor agonist comparable to dihydrotestosterone (DHT) [1][2][3].

Fmoc-Trp(5-OH)-OH
5-06939 5g Ask for price

Fmoc-Trp(5-OH)-OH
5-06940 25g Ask for price

Angiotensin 1/2 (1-5)
A1047-5 5 mg
EUR 142.8
Description: Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.Angiotensin I is formed by the action ofreninonangiotensinogen, an ?-2-globulin with 12 amino acids.

Angiotensin 1/2 (5-7)
A1049-5 5 mg
EUR 142.8
Description: Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

[Pyr5]-Substance P (5-11)
5-00288 4 x 5mg Ask for price

[Trp3, Arg5]-Ghrelin (1-5)
5-00313 4 x 5mg Ask for price

beta-Casomorphin (1-5) (bovine)
5-00475 4 x 5mg Ask for price

Angiotensin I/II (5-8)
5-00684 4 x 5mg Ask for price

Cholecystokinin Octapeptide (1-5) (desulfated)
5-00970 4 x 5mg Ask for price

HIV-gp41-Antigenic Peptide 5
5-01331 4 x 1mg Ask for price

2-Methyl-5-hydroxytryptamine hydrochloride
2768-5
EUR 222

pLenti-CLDN1 shRNA-5 Plasmid
PVTBAV04867-5 2 ug
EUR 356

2'-O-Methylpseudouridine-5'-Triphosphate
B7993-.5 5x100 µl (100 mM)
EUR 16827.6

2'-Fluoro-thymidine-5'-Triphosphate
B8035-.5 5x100 µl (100 mM)
EUR 2470.8

Helioxanthin derivative 5-4-2
B4700-5 5 mg
EUR 819.6
Description: Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 ?M, 0.29 ?M and 0.16 ?M, respectively [1].

3,3',5'-Triiodo-L-thyronine
B2017-5
EUR 274.8

5-(N,N-dimethyl)-Amiloride (hydrochloride)
C3505-5 5 mg
EUR 216
Description: 5-(N, N-dimethyl)-Amiloride (hydrochloride), a derivative of amiloride, is an inhibitor of NHE1, NHE2, and NHE3. The Na+/H+ exchanger (NHE) is a protein that has been involved in intracellular pH homeostasis of many mammalian cell types.

3-bromo-5-phenyl Salicylic Acid
C4516-5 5 mg
EUR 444
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor.

5-bromo-3-phenyl Salicylic Acid
C4610-5 5 mg
EUR 382.8

Nickel NTA Magnetic Agarose Bead (5%)
MagNTANi5-5 5ml suspension
EUR 174

7078D 5 PIPET 5ML STERILE STERILE
7078D-5 25/pk
EUR 260.4
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Fmoc-D-Trp(5-Br)-OH
5-04217 1g Ask for price

Fmoc-D-Trp(5-Br)-OH
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5-04224 5g Ask for price

Fmoc-D-Trp(5-F)-OH
5-04227 1g Ask for price

Fmoc-D-Trp(5-F)-OH
5-04228 5g Ask for price

Ac-DL-Trp(5-Br)-OH·DCHA
5-04229 1g Ask for price

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Beta-Sheet Breaker Peptide iA?5
A1005-5 5 mg
EUR 122.4
Description: Beta-Sheet Breaker Peptide iA?5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models.

beta-Casomorphin (1-5) amide (bovine)
5-00476 4 x 5mg Ask for price

cAMP Dependent PK Inhibitor (5-24)
5-00922 4 x 1mg Ask for price

Kinase Domain of Insulin Receptor (5)
5-01429 4 x 1mg Ask for price

2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate
B7959-.5 5x100 µl (100 mM)
EUR 2470.8

2'-Fluoro-2'-deoxycytidine-5'-Triphosphate
B7961-.5 5x100 µl (100 mM)
EUR 2470.8

2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate
B7962-.5 5x100 µl (100 mM)
EUR 2470.8

2'-Fluoro-2'-deoxyuridine-5'-Triphosphate
B7963-.5 5x100 µl (100 mM)
EUR 2470.8

CytoSelect Clonogenic Tumor Cell Isolation Kit (5 x 5 preps)
CBA-155-5 25 preps
EUR 3894
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis.

5-min. Genomic DNA Prep for PCR
P930-5 - Ask for price

DiagNano Silica-Coated Gold Nanoparticles, 5 nm
CG-5 10mL
EUR 862.8

2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide
C4686-5 5 mg
EUR 278.4

[D-Ala2]- beta-Casomorphin (1-5), bovine
5-00075 4 x 5mg Ask for price

[D-Pro2]-beta-Casomorphin (1-5) , bovine
5-00133 4 x 5mg Ask for price

beta-Endorphin (1-5) + (16-31), human
5-00488 4 x 1mg Ask for price

Biotin-Kinase Domain of Insulin Receptor (5)
5-00799 4 x 1mg Ask for price

cAMP Dependent PK Inhibitor (5-22), amide
5-00921 4 x 1mg Ask for price

Substance P (5-11)/Hepta-Substance P
5-01979 4 x 5mg Ask for price

S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
B2826-5
EUR 144

DiagNano Fluorophore Labeled Gold Nanoparticles, 5 nm
GFL-5 1 mL
EUR 1263.6

5-Hydroxytryptamine (5-HT) ELISA Kit
DLR-5-HT-Ge-48T 48T
EUR 562.8
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids.

5-Hydroxytryptamine (5-HT) ELISA Kit
DLR-5-HT-Ge-96T 96T
EUR 729.6
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids.

DiagNano Silica-Coated PEGylated Gold Nanoparticles, 5 nm
PG-5 10mL
EUR 719

[D-Ala2]- beta-Casomorphin (1-5) amide (bovine)
5-00074 4 x 5mg Ask for price

[D-Ala2, Met5]- ß-Casomorphin (1-5), bovine
5-00092 4 x 5mg Ask for price

[D-Pro2]-beta-Casomorphin (1-5) , bovine, amide
5-00134 4 x 5mg Ask for price

DiagNano Gold Nanoparticle Passive Conjugation Kit, 5 nm
GPK-5 1 kit
EUR 858

General 5-Hydroxytryptamine (5-HT) ELISA Kit
RD-5-HT-Ge-48Tests 48 Tests
EUR 467

General 5-Hydroxytryptamine (5-HT) ELISA Kit
RD-5-HT-Ge-96Tests 96 Tests
EUR 646

General 5-Hydroxytryptamine (5-HT) ELISA Kit
RDR-5-HT-Ge-48Tests 48 Tests
EUR 488

General 5-Hydroxytryptamine (5-HT) ELISA Kit
RDR-5-HT-Ge-96Tests 96 Tests
EUR 676

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit
DLR-5-HIAA-Ge-48T 48T
EUR 690
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids.

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit
DLR-5-HIAA-Ge-96T 96T
EUR 903.6
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids.

Checkit Pro C02 - 5 pack
CP-C02-5 5pack
EUR 248.4
Description: Pipette Checkit Pro model for 2uL pipettes. Pack of 5.

Checkit Pro C05 - 5 pack
CP-C05-5 5pack
EUR 237.6
Description: Pipette Checkit Pro model for 5uL pipettes. Pack of 5.

Checkit Pro C10 - 5 pack
CP-C10-5 5pack
EUR 237.6
Description: Pipette Checkit Pro model for 10uL pipettes. Pack of 5.

Checkit Pro C100 - 5 pack
CP-C100-5 5pack
EUR 214.8
Description: Pipette Checkit Pro model for 100uL pipettes. Pack of 5.

Checkit Pro C20 - 5 pack
CP-C20-5 5pack
EUR 225.6
Description: Pipette Checkit Pro model for 20uL pipettes. Pack of 5.

Checkit Pro C200 - 5 pack
CP-C200-5 5pack
EUR 214.8
Description: Pipette Checkit Pro model for 200uL pipettes. Pack of 5.

Checkit Pro C50 - 5 pack
CP-C50-5 5pack
EUR 214.8
Description: Pipette Checkit Pro model for 50uL pipettes. Pack of 5.

Single channel mini-pipette (130 mm) 5 ul, autoclavable
SCMP-5 1
EUR 92

survivin (baculoviral IAP repeat-containing protein 5) (21-28)
A1092-5 5 mg
EUR 268.8
Description: Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibition of apoptosis and mitosis regulation1.

[D-Ala2, DPro4, Tyr5] -beta-Casomorphin (1-5), amide
5-00089 4 x 5mg Ask for price

[D-Ala2, Hyp4, Tyr5]- beta-Casomorphin (1-5) amide
5-00090 4 x 5mg Ask for price

[D-Ala2, Met5]- beta-Casomorphin (1-5) , bovine , amide
5-00093 4 x 5mg Ask for price

General 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit
RDR-5-HIAA-Ge-48Tests 48 Tests
EUR 613

General 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit
RDR-5-HIAA-Ge-96Tests 96 Tests
EUR 854

OxiSelect Nitrotyrosine ELISA Kit (5 plates)
STA-305-5 5 x 96 assays
EUR 3240
Description: Nitric oxide influences a variety of biological processes including cell proliferation, apoptosis, neurotoxicity and extracellular matrix remodeling. Nitric oxide reacts with superoxide to form peroxynitrite, which in turn nitrates tyrosine residues in proteins. Nitrotyrosine therefore serves as a marker for peroxynitrite action in a variety of disease states and in conditions of cellular damage and oxidative stress. Our OxiSelect Nitrotyrosine ELISA Kit provides a sensitive method to measure the formation of 3-nitrotyrosine in proteins.

Sodium chloride 5 M, 1000 ml
12-9191-5 1000 ml
EUR 115.2

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (5 biotin/BSA)
7098-5
EUR 144

[D-Ala2, 4, Tyr5] -beta-Casomorphin (1-5), amide, bovine
5-00085 4 x 5mg Ask for price

[D-Glu5, D-Trp7, 9, 10]-Substance P (5-11)
5-00114 4 x 5mg Ask for price

[Des-Ala1, des-Gly2, His4, 5, D-Trp8]-Somatostatin-14
5-00162 4 x 5mg Ask for price

Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat)
5-01665 4 x 5mg Ask for price

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
RD-CA19-5-Hu-48Tests 48 Tests
EUR 563

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
RD-CA19-5-Hu-96Tests 96 Tests
EUR 783

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
RDR-CA19-5-Hu-48Tests 48 Tests
EUR 589

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
RDR-CA19-5-Hu-96Tests 96 Tests
EUR 820

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
DLR-CA19-5-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-5 (CA19-5) in samples from serum, plasma or other biological fluids.

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
DLR-CA19-5-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-5 (CA19-5) in samples from serum, plasma or other biological fluids.

[Tyr8]-Atrial Natriuretic Peptide (5-27), rat; [Tyr8]-Atriopeptin II, rat
5-00363 4 x 1mg Ask for price

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)
5-01666 4 x 5mg Ask for price

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1030-5
EUR 664

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1031-5
EUR 664

Immune profile in tumors of LC-COPD versus LC: No significant differences were observed in tumors between LC-COPD and LC patients for any study marker.Immune cell subtypes and cytokines are differentially expressed in lung tumors, and the presence of COPD elicited a decline in IgG-secreting plasma cell levels but not in other cell types.