The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by T regulatory (Treg), naturalkiller (NK), and plasma cells, as well as interleukin (IL)-10 and interferon-gamma, may differ within tumors of LC patients with/without COPD.
Treg (anti-CD3 and anti-forkhead boxP3 antibodies), NK (anti-NCR1 antibody), IgG (anti-CD138-IgG antibody), IgA (anti-CD138-IgA antibody) using immunohistochemistry, and both IL-10 and interferon-gamma (ELISA) were quantified in tumor and non-tumor specimens (thoracotomy for lung tumor resection) from 33 LC-COPD patients and 20 LC-only patients.
Immune profile in tumor versus non-tumor specimens: Treg cell counts significantly increased in tumors of both LC and LC-COPD patients, while in tumors of the latter group, IgG-secreting plasma cells significantly decreased and IL-10 increased. No significant differences were seen in levels of NK cells, IgA-secreting cells, IgA/IgG, or interferon-gamma.
2',3',5'-triacetyl-5-Azacytidine |
B2822-5 |
Biovision |
|
EUR 153 |
5-Iodotubercidin |
A3125-5 |
ApexBio |
5 mg |
EUR 168 |
Description: 5-Iodotubercidin (Itu) is a purine derivative and hence an inhibitor of adenosine kinase with an IC50 value of 26 nM [1]. Adenosine kinase is important in regulating the intracellular and extracellular concentrations of adenosine and hence diverse physiological actions of adenosine [2]. |
Thrombin Receptor Activator for Peptide 5 (TRAP-5) |
A1036-5 |
ApexBio |
5 mg |
EUR 102 |
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5),(C30H50N8O7), a peptide with the sequence NH2-Ser-Phe-Leu-Leu-Arg-COOH, MW= 634.76. coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response. |
5-fluoro 203 |
C4114-5 |
ApexBio |
5 mg |
EUR 154 |
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450. |
5'-deoxy Thymidine |
C4692-5 |
ApexBio |
5 mg |
EUR 180 |
Description: 5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines. |
Teicoplanin A2-5 |
C4938-5 |
ApexBio |
5 mg |
EUR 1157 |
Description: Teicoplanin A2-5, derived from Actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria. |
W-5 hydrochloride |
B6277-5 |
ApexBio |
5 mg |
EUR 116 |
5-Nonyloxytryptamine oxalate |
B6496-5 |
ApexBio |
5 mg |
EUR 154 |
2',5'-Dideoxyadenosine |
2770-5 |
Biovision |
|
EUR 240 |
5-Formylcytosine (5-fC) ELISA Kit |
MET-5102-5 |
Cell Biolabs |
5 x 96 assays |
EUR 2283 |
5-Carboxylcytosine (5-caC) ELISA Kit |
MET-5103-5 |
Cell Biolabs |
5 x 96 assays |
EUR 2283 |
2',5'-dideoxy Adenosine |
C3993-5 |
ApexBio |
5 mg |
EUR 189 |
Description: 2',5'-dideoxy Adenosine, a nucleoside analog, is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase [1]. Adenylyl cyclase is an enzyme with key regulatory roles in almost all cells. |
5-trans U-46619 |
C4261-5 |
ApexBio |
5 mg |
EUR 538 |
Description: 5-trans U-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of U-46619 [1]. U-46619 is a selective thromboxane A2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2]. |
5'-(N-Cyclopropyl)carboxamidoadenosine |
C4645-5 |
ApexBio |
5 mg |
EUR 128 |
5-Nitroso-8-quinolinol |
B2825-5 |
Biovision |
|
EUR 109 |
Individual Reaction Mix 5 |
G065-5 |
ABM |
200 reactions |
EUR 167 |
AICA riboside, 5'-phosphate |
9416-5 |
Biovision |
|
EUR 153 |
FAM azide, 5- isomer |
A8117-5 |
ApexBio |
5 mg |
EUR 166 |
Description: FAM azide for Click chemistry labeling. FAM remains one of the most popular fluorescent lablels for various application. Most instruments capable of fluorescence detection, ranging from plate readers to fluorescence microscopes, are able to work in FAM channel. |
ROX azide, 5- isomer |
A8126-5 |
ApexBio |
5 mg |
EUR 583 |
Description: ROX (rhodamine-X) azide, solid material, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. ROX is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield.Pure 5-isomer. |
TAMRA azide, 5- isomer |
A8129-5 |
ApexBio |
5 mg |
EUR 583 |
Description: TAMRA (TMR, tetramethylrhodamine) azide, solid compound, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. Pure 5-isomer.TAMRA is often used as FRET acceptor for FAM fluorophore. |
Secretin (5 - 27), porcine |
5-01917 |
CHI Scientific |
4 x 1mg |
Ask for price |
Necrosis Inhibitor, Necrox-5 |
2229-5 |
Biovision |
|
EUR 615 |
5?-dihydro-11-keto Testosterone |
C4317-5 |
ApexBio |
5 mg |
EUR 586 |
Description: 5?-dihydro-11-keto Testosterone (11KDHT) is a full androgen receptor agonist comparable to dihydrotestosterone (DHT) [1][2][3]. |
3,3',5'-Triiodo-L-thyronine |
C5014-5 |
ApexBio |
5 mg |
EUR 134 |
Description: 3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TR? and TR? antagonist [1]. |
3,3',5'-Triiodo-L-thyronine |
B2017-5 |
Biovision |
|
EUR 229 |
Helioxanthin derivative 5-4-2 |
B4700-5 |
ApexBio |
5 mg |
EUR 683 |
Description: Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 ?M, 0.29 ?M and 0.16 ?M, respectively [1]. |
2'-O-Methylpseudouridine-5'-Triphosphate |
B7993-.5 |
ApexBio |
5x100 µl (100 mM) |
EUR 14023 |
2'-Fluoro-thymidine-5'-Triphosphate |
B8035-.5 |
ApexBio |
5x100 µl (100 mM) |
EUR 2059 |
Angiotensin 1/2 (1-5) |
A1047-5 |
ApexBio |
5 mg |
EUR 119 |
Description: Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.Angiotensin I is formed by the action ofreninonangiotensinogen, an ?-2-globulin with 12 amino acids. |
Angiotensin 1/2 (5-7) |
A1049-5 |
ApexBio |
5 mg |
EUR 119 |
Description: Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. |
[Pyr5]-Substance P (5-11) |
5-00288 |
CHI Scientific |
4 x 5mg |
Ask for price |
[Trp3, Arg5]-Ghrelin (1-5) |
5-00313 |
CHI Scientific |
4 x 5mg |
Ask for price |
beta-Casomorphin (1-5) (bovine) |
5-00475 |
CHI Scientific |
4 x 5mg |
Ask for price |
Cholecystokinin Octapeptide (1-5) (desulfated) |
5-00970 |
CHI Scientific |
4 x 5mg |
Ask for price |
HIV-gp41-Antigenic Peptide 5 |
5-01331 |
CHI Scientific |
4 x 1mg |
Ask for price |
2-Methyl-5-hydroxytryptamine hydrochloride |
2768-5 |
Biovision |
|
EUR 185 |
Magnetic Beads (DNA) 5 mL |
P920-5 |
101Bio |
NULL |
EUR 0 |
3-bromo-5-phenyl Salicylic Acid |
C4516-5 |
ApexBio |
5 mg |
EUR 370 |
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor. |
5-bromo-3-phenyl Salicylic Acid |
C4610-5 |
ApexBio |
5 mg |
EUR 319 |
2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate |
B7959-.5 |
ApexBio |
5x100 µl (100 mM) |
EUR 2059 |
2'-Fluoro-2'-deoxycytidine-5'-Triphosphate |
B7961-.5 |
ApexBio |
5x100 µl (100 mM) |
EUR 2059 |
2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate |
B7962-.5 |
ApexBio |
5x100 µl (100 mM) |
EUR 2059 |
2'-Fluoro-2'-deoxyuridine-5'-Triphosphate |
B7963-.5 |
ApexBio |
5x100 µl (100 mM) |
EUR 2059 |
5-(N,N-dimethyl)-Amiloride (hydrochloride) |
C3505-5 |
ApexBio |
5 mg |
EUR 180 |
Description: 5-(N, N-dimethyl)-Amiloride (hydrochloride), a derivative of amiloride, is an inhibitor of NHE1, NHE2, and NHE3. The Na+/H+ exchanger (NHE) is a protein that has been involved in intracellular pH homeostasis of many mammalian cell types. |
Beta-Sheet Breaker Peptide iA?5 |
A1005-5 |
ApexBio |
5 mg |
EUR 102 |
Description: Beta-Sheet Breaker Peptide iA?5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models. |
beta-Casomorphin (1-5) amide (bovine) |
5-00476 |
CHI Scientific |
4 x 5mg |
Ask for price |
cAMP Dependent PK Inhibitor (5-24) |
5-00922 |
CHI Scientific |
4 x 1mg |
Ask for price |
Kinase Domain of Insulin Receptor (5) |
5-01429 |
CHI Scientific |
4 x 1mg |
Ask for price |
Fmoc-2-amino-5-Methoxybenzoic acid |
5-04549 |
CHI Scientific |
1g |
Ask for price |
Fmoc-2-amino-5-Methoxybenzoic acid |
5-04550 |
CHI Scientific |
5g |
Ask for price |
7078D 5 PIPET 5ML STERILE STERILE |
7078D-5 |
CORNING |
25/pk |
EUR 217 |
Description: Disposable Pipets; Disposable Pipets, Serological, Misc |
Nickel NTA Magnetic Agarose Bead (5%) |
MagNTANi5-5 |
ABTBeads |
5ml suspension |
EUR 174 |
CytoSelect Clonogenic Tumor Cell Isolation Kit (5 x 5 preps) |
CBA-155-5 |
Cell Biolabs |
25 preps |
EUR 3245 |
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis. |
5-Hydroxytryptamine (5-HT) ELISA Kit |
DLR-5-HT-Ge-48T |
DL Develop |
48T |
EUR 469 |
- Should the 5-Hydroxytryptamine (5-HT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids. |
5-Hydroxytryptamine (5-HT) ELISA Kit |
DLR-5-HT-Ge-96T |
DL Develop |
96T |
EUR 608 |
- Should the 5-Hydroxytryptamine (5-HT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids. |
2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide |
C4686-5 |
ApexBio |
5 mg |
EUR 232 |
S-(5'-Adenosyl)-L-methionine chloride (hydrochloride) |
B2826-5 |
Biovision |
|
EUR 120 |
[D-Ala2]- beta-Casomorphin (1-5), bovine |
5-00075 |
CHI Scientific |
4 x 5mg |
Ask for price |
[D-Pro2]-beta-Casomorphin (1-5) , bovine |
5-00133 |
CHI Scientific |
4 x 5mg |
Ask for price |
beta-Endorphin (1-5) + (16-31), human |
5-00488 |
CHI Scientific |
4 x 1mg |
Ask for price |
Biotin-Kinase Domain of Insulin Receptor (5) |
5-00799 |
CHI Scientific |
4 x 1mg |
Ask for price |
cAMP Dependent PK Inhibitor (5-22), amide |
5-00921 |
CHI Scientific |
4 x 1mg |
Ask for price |
Substance P (5-11)/Hepta-Substance P |
5-01979 |
CHI Scientific |
4 x 5mg |
Ask for price |
5-min. Genomic DNA Prep for PCR |
P930-5 |
101Bio |
NULL |
EUR 0 |
5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit |
DLR-5-HIAA-Ge-48T |
DL Develop |
48T |
EUR 575 |
- Should the 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids. |
5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit |
DLR-5-HIAA-Ge-96T |
DL Develop |
96T |
EUR 753 |
- Should the 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids. |
General 5-Hydroxytryptamine (5-HT) ELISA Kit |
RD-5-HT-Ge-48Tests |
Reddot Biotech |
48 Tests |
EUR 467 |
General 5-Hydroxytryptamine (5-HT) ELISA Kit |
RD-5-HT-Ge-96Tests |
Reddot Biotech |
96 Tests |
EUR 646 |
General 5-Hydroxytryptamine (5-HT) ELISA Kit |
RDR-5-HT-Ge-48Tests |
Reddot Biotech |
48 Tests |
EUR 488 |
General 5-Hydroxytryptamine (5-HT) ELISA Kit |
RDR-5-HT-Ge-96Tests |
Reddot Biotech |
96 Tests |
EUR 676 |
[D-Ala2]- beta-Casomorphin (1-5) amide (bovine) |
5-00074 |
CHI Scientific |
4 x 5mg |
Ask for price |
[D-Ala2, Met5]- ß-Casomorphin (1-5), bovine |
5-00092 |
CHI Scientific |
4 x 5mg |
Ask for price |
[D-Pro2]-beta-Casomorphin (1-5) , bovine, amide |
5-00134 |
CHI Scientific |
4 x 5mg |
Ask for price |
Checkit Pro C02 - 5 pack |
CP-C02-5 |
Next Advance |
5pack |
EUR 207 |
Description: Pipette Checkit Pro model for 2uL pipettes. Pack of 5. |
Checkit Pro C05 - 5 pack |
CP-C05-5 |
Next Advance |
5pack |
EUR 198 |
Description: Pipette Checkit Pro model for 5uL pipettes. Pack of 5. |
Checkit Pro C10 - 5 pack |
CP-C10-5 |
Next Advance |
5pack |
EUR 198 |
Description: Pipette Checkit Pro model for 10uL pipettes. Pack of 5. |
Checkit Pro C100 - 5 pack |
CP-C100-5 |
Next Advance |
5pack |
EUR 179 |
Description: Pipette Checkit Pro model for 100uL pipettes. Pack of 5. |
Checkit Pro C20 - 5 pack |
CP-C20-5 |
Next Advance |
5pack |
EUR 188 |
Description: Pipette Checkit Pro model for 20uL pipettes. Pack of 5. |
Checkit Pro C200 - 5 pack |
CP-C200-5 |
Next Advance |
5pack |
EUR 179 |
Description: Pipette Checkit Pro model for 200uL pipettes. Pack of 5. |
Checkit Pro C50 - 5 pack |
CP-C50-5 |
Next Advance |
5pack |
EUR 179 |
Description: Pipette Checkit Pro model for 50uL pipettes. Pack of 5. |
General 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit |
RDR-5-HIAA-Ge-48Tests |
Reddot Biotech |
48 Tests |
EUR 613 |
General 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit |
RDR-5-HIAA-Ge-96Tests |
Reddot Biotech |
96 Tests |
EUR 854 |
survivin (baculoviral IAP repeat-containing protein 5) (21-28) |
A1092-5 |
ApexBio |
5 mg |
EUR 224 |
Description: Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibition of apoptosis and mitosis regulation1. |
[D-Ala2, DPro4, Tyr5] -beta-Casomorphin (1-5), amide |
5-00089 |
CHI Scientific |
4 x 5mg |
Ask for price |
[D-Ala2, Hyp4, Tyr5]- beta-Casomorphin (1-5) amide |
5-00090 |
CHI Scientific |
4 x 5mg |
Ask for price |
[D-Ala2, Met5]- beta-Casomorphin (1-5) , bovine , amide |
5-00093 |
CHI Scientific |
4 x 5mg |
Ask for price |
Single channel mini-pipette (130 mm) 5 ul, autoclavable |
SCMP-5 |
Alpha Diagnostics |
1 |
EUR 92 |
Sodium chloride 5 M, 1000 ml |
12-9191-5 |
Medicago |
1000 ml |
EUR 96 |
OxiSelect Nitrotyrosine ELISA Kit (5 plates) |
STA-305-5 |
Cell Biolabs |
5 x 96 assays |
EUR 3240 |
Description: Nitric oxide influences a variety of biological processes including cell proliferation, apoptosis, neurotoxicity and extracellular matrix remodeling. Nitric oxide reacts with superoxide to form peroxynitrite, which in turn nitrates tyrosine residues in proteins. Nitrotyrosine therefore serves as a marker for peroxynitrite action in a variety of disease states and in conditions of cellular damage and oxidative stress. Our OxiSelect Nitrotyrosine ELISA Kit provides a sensitive method to measure the formation of 3-nitrotyrosine in proteins. |
Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit |
DLR-CA19-5-Hu-48T |
DL Develop |
48T |
EUR 554 |
- Should the Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-5 (CA19-5) in samples from serum, plasma or other biological fluids. |
Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit |
DLR-CA19-5-Hu-96T |
DL Develop |
96T |
EUR 725 |
- Should the Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-5 (CA19-5) in samples from serum, plasma or other biological fluids. |
Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit |
RD-CA19-5-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 563 |
Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit |
RD-CA19-5-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 783 |
Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit |
RDR-CA19-5-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 589 |
Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit |
RDR-CA19-5-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 820 |
[D-Ala2, 4, Tyr5] -beta-Casomorphin (1-5), amide, bovine |
5-00085 |
CHI Scientific |
4 x 5mg |
Ask for price |
[D-Glu5, D-Trp7, 9, 10]-Substance P (5-11) |
5-00114 |
CHI Scientific |
4 x 5mg |
Ask for price |
[Des-Ala1, des-Gly2, His4, 5, D-Trp8]-Somatostatin-14 |
5-00162 |
CHI Scientific |
4 x 5mg |
Ask for price |
Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) |
5-01665 |
CHI Scientific |
4 x 5mg |
Ask for price |
Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (5 biotin/BSA) |
7098-5 |
Biovision |
|
EUR 120 |
Protein G Affinity Cartridges 5ml,1 or 5 cartridges with 5 ml of resin each one |
AF4PG-Ctg5-5 |
ABTBeads |
5 x 5ml |
EUR 726 |
Nickel NTA Agarose Cartridges 5ml,1 or 5 cartridges with 5 ml of resin each one |
6BCL-NTANiCtg5-5 |
ABTBeads |
5 x 5ml |
EUR 411 |
Immune profile in tumors of LC-COPD versus LC: No significant differences were observed in tumors between LC-COPD and LC patients for any study marker.Immune cell subtypes and cytokines are differentially expressed in lung tumors, and the presence of COPD elicited a decline in IgG-secreting plasma cell levels but not in other cell types.