Immune Cell Subtypes and Cytokines in Lung Tumor Microenvironment: Influence of COPD.

The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by T regulatory (Treg), naturalkiller (NK), and plasma cells, as well as interleukin (IL)-10 and interferon-gamma, may differ within tumors of LC patients with/without COPD.

Treg (anti-CD3 and anti-forkhead boxP3 antibodies), NK (anti-NCR1 antibody), IgG (anti-CD138-IgG antibody), IgA (anti-CD138-IgA antibody) using immunohistochemistry, and both IL-10 and interferon-gamma (ELISA) were quantified in tumor and non-tumor specimens (thoracotomy for lung tumor resection) from 33 LC-COPD patients and 20 LC-only patients.

Immune profile in tumor versus non-tumor specimens: Treg cell counts significantly increased in tumors of both LC and LC-COPD patients, while in tumors of the latter group, IgG-secreting plasma cells significantly decreased and IL-10 increased. No significant differences were seen in levels of NK cells, IgA-secreting cells, IgA/IgG, or interferon-gamma.

CHD-5
2693-5
EUR 153

Necrostatin-5
1865-5
EUR 126

GNF-5
B1329-5
EUR 142

Histatin 5
5-01307 4 x 1mg Ask for price

5-Iodotubercidin
A3125-5 5 mg
EUR 168
Description: 5-Iodotubercidin (Itu) is a purine derivative and hence an inhibitor of adenosine kinase with an IC50 value of 26 nM [1]. Adenosine kinase is important in regulating the intracellular and extracellular concentrations of adenosine and hence diverse physiological actions of adenosine [2].

5-ROX
B8212-5 5 mg
EUR 195

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
A1036-5 5 mg
EUR 102
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5),(C30H50N8O7), a peptide with the sequence NH2-Ser-Phe-Leu-Leu-Arg-COOH, MW= 634.76. coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response.

2',5'-Dideoxyadenosine
2770-5
EUR 240

TRAP-5 amide
5-02019 4 x 5mg Ask for price

[Cit5]-TRAP-5
5-00062 4 x 5mg Ask for price

A-VI-5
5-00524 4 x 5mg Ask for price

ACTH(5-10)
5-00605 4 x 5mg Ask for price

Angiotensin (1-5)
5-00676 4 x 5mg Ask for price

Bradykinin (1-5)
5-00852 4 x 5mg Ask for price

W-5 hydrochloride
B6277-5 5 mg
EUR 116

5-Nonyloxytryptamine oxalate
B6496-5 5 mg
EUR 154

5'-deoxy Thymidine
C4692-5 5 mg
EUR 180
Description: 5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines.

Teicoplanin A2-5
C4938-5 5 mg
EUR 1157
Description: Teicoplanin A2-5, derived from Actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria.

5-fluoro 203
C4114-5 5 mg
EUR 154
Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450.

5-Formylcytosine (5-fC) ELISA Kit
MET-5102-5 5 x 96 assays
EUR 2283

5-Carboxylcytosine (5-caC) ELISA Kit
MET-5103-5 5 x 96 assays
EUR 2283

AICA riboside, 5'-phosphate
9416-5
EUR 153

Individual Reaction Mix 5
G065-5 200 reactions
EUR 167

Necrosis Inhibitor, Necrox-5
2229-5
EUR 615

5-Nitroso-8-quinolinol
B2825-5
EUR 109

Secretin (5 - 27), porcine
5-01917 4 x 1mg Ask for price

SH2 Domain Ligand (5)
5-01929 4 x 5mg Ask for price

Boc-5-Ava-OH
5-04607 25g Ask for price

Boc-5-Ava-OH
5-04608 100g Ask for price

Fmoc-5-Ava-OH
5-04609 5g Ask for price

Fmoc-5-Ava-OH
5-04610 25g Ask for price

Dok- 5 (263 - 275)
5-01048 4 x 5mg Ask for price

5'-(N-Cyclopropyl)carboxamidoadenosine
C4645-5 5 mg
EUR 128

2',5'-dideoxy Adenosine
C3993-5 5 mg
EUR 189
Description: 2',5'-dideoxy Adenosine, a nucleoside analog, is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase [1]. Adenylyl cyclase is an enzyme with key regulatory roles in almost all cells.

FAM azide, 5- isomer
A8117-5 5 mg
EUR 166
Description: FAM azide for Click chemistry labeling. FAM remains one of the most popular fluorescent lablels for various application. Most instruments capable of fluorescence detection, ranging from plate readers to fluorescence microscopes, are able to work in FAM channel.

ROX azide, 5- isomer
A8126-5 5 mg
EUR 583
Description: ROX (rhodamine-X) azide, solid material, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. ROX is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield.Pure 5-isomer.

TAMRA azide, 5- isomer
A8129-5 5 mg
EUR 583
Description: TAMRA (TMR, tetramethylrhodamine) azide, solid compound, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. Pure 5-isomer.TAMRA is often used as FRET acceptor for FAM fluorophore.

5-trans U-46619
C4261-5 5 mg
EUR 538
Description: 5-trans U-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of U-46619 [1]. U-46619 is a selective thromboxane A2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2].

2-Methyl-5-hydroxytryptamine hydrochloride
2768-5
EUR 185

3,3',5'-Triiodo-L-thyronine
B2017-5
EUR 229

pLenti-CLDN1 shRNA-5 Plasmid
PVTBAV04867-5 2 ug
EUR 356

Fmoc-Trp(5-OH)-OH
5-06939 5g Ask for price

Fmoc-Trp(5-OH)-OH
5-06940 25g Ask for price

[Pyr5]-Substance P (5-11)
5-00288 4 x 5mg Ask for price

[Trp3, Arg5]-Ghrelin (1-5)
5-00313 4 x 5mg Ask for price

beta-Casomorphin (1-5) (bovine)
5-00475 4 x 5mg Ask for price

Angiotensin I/II (5-8)
5-00684 4 x 5mg Ask for price

Cholecystokinin Octapeptide (1-5) (desulfated)
5-00970 4 x 5mg Ask for price

HIV-gp41-Antigenic Peptide 5
5-01331 4 x 1mg Ask for price

Magnetic Beads (DNA) 5 mL
P920-5 - Ask for price

Angiotensin 1/2 (1-5)
A1047-5 5 mg
EUR 119
Description: Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.Angiotensin I is formed by the action ofreninonangiotensinogen, an ?-2-globulin with 12 amino acids.

Angiotensin 1/2 (5-7)
A1049-5 5 mg
EUR 119
Description: Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

Helioxanthin derivative 5-4-2
B4700-5 5 mg
EUR 683
Description: Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 ?M, 0.29 ?M and 0.16 ?M, respectively [1].

2'-O-Methylpseudouridine-5'-Triphosphate
B7993-.5 5x100 µl (100 mM)
EUR 14023

2'-Fluoro-thymidine-5'-Triphosphate
B8035-.5 5x100 µl (100 mM)
EUR 2059

3,3',5'-Triiodo-L-thyronine
C5014-5 5 mg
EUR 134
Description: 3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TR? and TR? antagonist [1].

5?-dihydro-11-keto Testosterone
C4317-5 5 mg
EUR 586
Description: 5?-dihydro-11-keto Testosterone (11KDHT) is a full androgen receptor agonist comparable to dihydrotestosterone (DHT) [1][2][3].

Nickel NTA Magnetic Agarose Bead (5%)
MagNTANi5-5 5ml suspension
EUR 174

7078D 5 PIPET 5ML STERILE STERILE
7078D-5 25/pk
EUR 217
Description: Disposable Pipets; Disposable Pipets, Serological, Misc

Fmoc-D-Trp(5-Br)-OH
5-04217 1g Ask for price

Fmoc-D-Trp(5-Br)-OH
5-04218 5g Ask for price

Fmoc-D-Trp(5-Cl)-OH
5-04223 1g Ask for price

Fmoc-D-Trp(5-Cl)-OH
5-04224 5g Ask for price

Fmoc-D-Trp(5-F)-OH
5-04227 1g Ask for price

Fmoc-D-Trp(5-F)-OH
5-04228 5g Ask for price

Ac-DL-Trp(5-Br)-OH·DCHA
5-04229 1g Ask for price

Ac-DL-Trp(5-Br)-OH·DCHA
5-04230 5g Ask for price

Ac-DL-Trp(5-Cl)-OH·DCHA
5-04231 1g Ask for price

Ac-DL-Trp(5-Cl)-OH·DCHA
5-04232 5g Ask for price

Fmoc-2-amino-5-Methoxybenzoic acid
5-04549 1g Ask for price

Fmoc-2-amino-5-Methoxybenzoic acid
5-04550 5g Ask for price

Fmoc-3-Ala(5-Thiazoyl)-OH
5-05361 1g Ask for price

Fmoc-3-Ala(5-Thiazoyl)-OH
5-05362 5g Ask for price

beta-Casomorphin (1-5) amide (bovine)
5-00476 4 x 5mg Ask for price

cAMP Dependent PK Inhibitor (5-24)
5-00922 4 x 1mg Ask for price

Kinase Domain of Insulin Receptor (5)
5-01429 4 x 1mg Ask for price

Beta-Sheet Breaker Peptide iA?5
A1005-5 5 mg
EUR 102
Description: Beta-Sheet Breaker Peptide iA?5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models.

2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate
B7959-.5 5x100 µl (100 mM)
EUR 2059

2'-Fluoro-2'-deoxycytidine-5'-Triphosphate
B7961-.5 5x100 µl (100 mM)
EUR 2059

2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate
B7962-.5 5x100 µl (100 mM)
EUR 2059

2'-Fluoro-2'-deoxyuridine-5'-Triphosphate
B7963-.5 5x100 µl (100 mM)
EUR 2059

3-bromo-5-phenyl Salicylic Acid
C4516-5 5 mg
EUR 370
Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor.

5-bromo-3-phenyl Salicylic Acid
C4610-5 5 mg
EUR 319

5-(N,N-dimethyl)-Amiloride (hydrochloride)
C3505-5 5 mg
EUR 180
Description: 5-(N, N-dimethyl)-Amiloride (hydrochloride), a derivative of amiloride, is an inhibitor of NHE1, NHE2, and NHE3. The Na+/H+ exchanger (NHE) is a protein that has been involved in intracellular pH homeostasis of many mammalian cell types.

CytoSelect Clonogenic Tumor Cell Isolation Kit (5 x 5 preps)
CBA-155-5 25 preps
EUR 3245
Description: Many solid tumors contain heterogeneous populations of normal and cancerous cells. Separation of these cell populations is key to an accurate assessment of the true genotypic and phenotypic differences between normal and tumor cells. Our CytoSelect Clonogenic Tumor Cell Isolation Kit uses a proprietary semisolid agar medium to facilitate formation of colonies by cells from solid tumors. Colonies are grown in either a 6-well plate or a 35mm culture dish. These colonies are isolated away from single (i.e. normal) cells by size filtration. The viable cells from these colonies can be easily recovered for further analysis.

5-Hydroxytryptamine (5-HT) ELISA Kit
DLR-5-HT-Ge-48T 48T
EUR 469
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids.

5-Hydroxytryptamine (5-HT) ELISA Kit
DLR-5-HT-Ge-96T 96T
EUR 608
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxytryptamine (5-HT) in samples from serum, plasma or other biological fluids.

S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
B2826-5
EUR 120

DiagNano Fluorophore Labeled Gold Nanoparticles, 5 nm
GFL-5 1 mL
EUR 1053

DiagNano Silica-Coated Gold Nanoparticles, 5 nm
CG-5 10mL
EUR 719

Substance P (5-11)/Hepta-Substance P
5-01979 4 x 5mg Ask for price

[D-Ala2]- beta-Casomorphin (1-5), bovine
5-00075 4 x 5mg Ask for price

[D-Pro2]-beta-Casomorphin (1-5) , bovine
5-00133 4 x 5mg Ask for price

beta-Endorphin (1-5) + (16-31), human
5-00488 4 x 1mg Ask for price

Biotin-Kinase Domain of Insulin Receptor (5)
5-00799 4 x 1mg Ask for price

cAMP Dependent PK Inhibitor (5-22), amide
5-00921 4 x 1mg Ask for price

5-min. Genomic DNA Prep for PCR
P930-5 - Ask for price

2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide
C4686-5 5 mg
EUR 232

General 5-Hydroxytryptamine (5-HT) ELISA Kit
RD-5-HT-Ge-48Tests 48 Tests
EUR 467

General 5-Hydroxytryptamine (5-HT) ELISA Kit
RD-5-HT-Ge-96Tests 96 Tests
EUR 646

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit
DLR-5-HIAA-Ge-48T 48T
EUR 575
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids.

5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit
DLR-5-HIAA-Ge-96T 96T
EUR 753
Description: A competitive inhibition quantitative ELISA assay kit for detection of 5-Hydroxyindoleacetic Acid (5-HIAA) in samples from serum, plasma, tissue homogenates or other biological fluids.

General 5-Hydroxytryptamine (5-HT) ELISA Kit
RDR-5-HT-Ge-48Tests 48 Tests
EUR 488

General 5-Hydroxytryptamine (5-HT) ELISA Kit
RDR-5-HT-Ge-96Tests 96 Tests
EUR 676

Checkit Pro C02 - 5 pack
CP-C02-5 5pack
EUR 207
Description: Pipette Checkit Pro model for 2uL pipettes. Pack of 5.

Checkit Pro C05 - 5 pack
CP-C05-5 5pack
EUR 198
Description: Pipette Checkit Pro model for 5uL pipettes. Pack of 5.

Checkit Pro C10 - 5 pack
CP-C10-5 5pack
EUR 198
Description: Pipette Checkit Pro model for 10uL pipettes. Pack of 5.

Checkit Pro C100 - 5 pack
CP-C100-5 5pack
EUR 179
Description: Pipette Checkit Pro model for 100uL pipettes. Pack of 5.

Checkit Pro C20 - 5 pack
CP-C20-5 5pack
EUR 188
Description: Pipette Checkit Pro model for 20uL pipettes. Pack of 5.

Checkit Pro C200 - 5 pack
CP-C200-5 5pack
EUR 179
Description: Pipette Checkit Pro model for 200uL pipettes. Pack of 5.

Checkit Pro C50 - 5 pack
CP-C50-5 5pack
EUR 179
Description: Pipette Checkit Pro model for 50uL pipettes. Pack of 5.

DiagNano Gold Nanoparticle Passive Conjugation Kit, 5 nm
GPK-5 1 kit
EUR 715

DiagNano Silica-Coated PEGylated Gold Nanoparticles, 5 nm
PG-5 10mL
EUR 719

[D-Ala2]- beta-Casomorphin (1-5) amide (bovine)
5-00074 4 x 5mg Ask for price

[D-Ala2, Met5]- ß-Casomorphin (1-5), bovine
5-00092 4 x 5mg Ask for price

[D-Pro2]-beta-Casomorphin (1-5) , bovine, amide
5-00134 4 x 5mg Ask for price

General 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit
RDR-5-HIAA-Ge-48Tests 48 Tests
EUR 613

General 5-Hydroxyindoleacetic Acid (5-HIAA) ELISA Kit
RDR-5-HIAA-Ge-96Tests 96 Tests
EUR 854

[D-Ala2, DPro4, Tyr5] -beta-Casomorphin (1-5), amide
5-00089 4 x 5mg Ask for price

[D-Ala2, Hyp4, Tyr5]- beta-Casomorphin (1-5) amide
5-00090 4 x 5mg Ask for price

[D-Ala2, Met5]- beta-Casomorphin (1-5) , bovine , amide
5-00093 4 x 5mg Ask for price

survivin (baculoviral IAP repeat-containing protein 5) (21-28)
A1092-5 5 mg
EUR 224
Description: Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibition of apoptosis and mitosis regulation1.

Single channel mini-pipette (130 mm) 5 ul, autoclavable
SCMP-5 1
EUR 92

Sodium chloride 5 M, 1000 ml
12-9191-5 1000 ml
EUR 96

OxiSelect Nitrotyrosine ELISA Kit (5 plates)
STA-305-5 5 x 96 assays
EUR 3240
Description: Nitric oxide influences a variety of biological processes including cell proliferation, apoptosis, neurotoxicity and extracellular matrix remodeling. Nitric oxide reacts with superoxide to form peroxynitrite, which in turn nitrates tyrosine residues in proteins. Nitrotyrosine therefore serves as a marker for peroxynitrite action in a variety of disease states and in conditions of cellular damage and oxidative stress. Our OxiSelect Nitrotyrosine ELISA Kit provides a sensitive method to measure the formation of 3-nitrotyrosine in proteins.

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
DLR-CA19-5-Hu-48T 48T
EUR 554
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-5 (CA19-5) in samples from serum, plasma or other biological fluids.

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
DLR-CA19-5-Hu-96T 96T
EUR 725
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 19-5 (CA19-5) in samples from serum, plasma or other biological fluids.

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
RD-CA19-5-Hu-48Tests 48 Tests
EUR 563

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
RD-CA19-5-Hu-96Tests 96 Tests
EUR 783

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
RDR-CA19-5-Hu-48Tests 48 Tests
EUR 589

Human Carbohydrate Antigen 19-5 (CA19-5) ELISA Kit
RDR-CA19-5-Hu-96Tests 96 Tests
EUR 820

Biotinylated Bovine Serum Albumin (Biotin-LC-BSA) (5 biotin/BSA)
7098-5
EUR 120

Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat)
5-01665 4 x 5mg Ask for price

[D-Ala2, 4, Tyr5] -beta-Casomorphin (1-5), amide, bovine
5-00085 4 x 5mg Ask for price

[D-Glu5, D-Trp7, 9, 10]-Substance P (5-11)
5-00114 4 x 5mg Ask for price

[Des-Ala1, des-Gly2, His4, 5, D-Trp8]-Somatostatin-14
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Protein G Affinity Cartridges 5ml,1 or 5 cartridges with 5 ml of resin each one
AF4PG-Ctg5-5 5 x 5ml
EUR 726

Nickel NTA Agarose Cartridges 5ml,1 or 5 cartridges with 5 ml of resin each one
6BCL-NTANiCtg5-5 5 x 5ml
EUR 411

Sodium hydroxide powder 5 M, 1000 ml
12-9183-5 1000 ml
EUR 122

OxiSelect Protein Carbonyl ELISA Kit (5 plates)
STA-310-5 5 x 96 assays
EUR 3240
Description: The most common products of protein oxidation in biological samples are the carbonyl derivatives of proline, lysine, arginine and threonine residues. Such derivatives are chemically stable and serve as markers for oxidative stress in most types of reactive oxygen species. Our OxiSelect Protein Carbonyl ELISA Kit provides a rapid, efficient method for the detection of protein carbonyl residues. The ELISA format is perfect for higher throughput and high sensitivity; we have eliminated concentration and precipitation steps allowing greater sample retention.

Immune profile in tumors of LC-COPD versus LC: No significant differences were observed in tumors between LC-COPD and LC patients for any study marker.Immune cell subtypes and cytokines are differentially expressed in lung tumors, and the presence of COPD elicited a decline in IgG-secreting plasma cell levels but not in other cell types.