Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of virally contaminated and malignant cells. The steadiness between activating and inhibitory alerts derived from NK floor receptors govern the NK cell immune response. The cytoskeleton facilitates most NK cell effector capabilities, akin to motility, infiltration, conjugation with goal cells, immunological synapse meeting, and cytotoxicity. Though many research have characterised signaling pathways that promote actin reorganization in immune cells, it isn’t utterly clear how specific cytoskeletal architectures at the immunological synapse promote effector capabilities, and how cytoskeletal dynamics influence downstream signaling pathways and activation.
Moreover, pioneering research using superior imaging methods have solely begun to uncover the architectural complexity dictating the NK cell activation threshold; it’s changing into clear {that a} distinct group of the cytoskeleton and signaling receptors at the NK immunological synapse performs a decisive position in activation and tolerance. Here, we evaluate the roles of the actin cytoskeleton in NK cells. We deal with how actin dynamics influence cytolytic granule secretion, NK cell motility, and NK cell infiltration by way of tissues into inflammatory websites. We can even describe the further cytoskeletal elements, non-muscle Myosin II and microtubules that play pivotal roles in NK cell exercise.
Expression of programmed cell loss of life protein 1 (PD-1) on pure killer (NK) cells has been tough to analyze on human NK cells. By testing industrial clones and novel anti-PD-1 reagents, we discovered expression of practical PD-1 on resting human NK cells in wholesome people and reconstituting NK cells early after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Peripheral blood samples from wholesome people and transplant recipients had been stained for PD-1 expression utilizing the industrial anti-PD-1 clone PD1.3.1.3, fluorescein isothiocyanate (FITC)-labeled pembrolizumab, or an FITC-labeled single-chain variable fragment (scFv) reagent comprised of pembrolizumab.
These reagents recognized low but constant basal PD-1 expression on resting NK cells, a discovering verified by discovering decrease PD-1 transcripts in sorted NK cells in contrast with these in resting or activated T cells. An enhance in PD-1 expression was recognized on paired resting NK cells after allo-HSCT. Blockade of PD-1 on resting NK cells from wholesome donors with pembrolizumab didn’t improve NK operate towards programmed death-ligand 1 (PD-L1)-expressing tumor traces, however blocking with its scFv by-product resulted in a twofold enhance in NK cell degranulation and up to a fourfold enhance in cytokine manufacturing.
In assist of this mechanism, PD-L1 overexpression of Okay562 targets suppressed NK cell operate. Interleukin-15 (IL-15) exercise was potent and couldn’t be additional enhanced by PD-1 blockade. An identical enhance in operate was noticed with scFv PD-1 blockade on resting blood NK cells after allo-HSCT. We determine the practical significance of the PD-1/PD-L1 axis on human NK cells in which blockade or activation to overcome inhibition will improve NK cell-mediated antitumor management. Furthermore, particular emphasis might be positioned on the position of the cytoskeleton in meeting of immunological synapses, and how mutations or downregulation of cytoskeletal accent proteins influence NK cell operate in well being and illness.
Lack of Viral Load Within Chronic Lymphoproliferative Disorder of Natural Killer Cells: What Is Outside the Leukemic Clone?
Large granular lymphocyte leukemias (LGLL) are sustained by proliferating cytotoxic T cells or NK cells, as occurs in Chronic Lymphoproliferative Disorder of Natural Killer cells (CLPD-NK), whose etiology is simply partly understood. Different hypotheses have been proposed on the unique occasions triggering NK cell hyperactivation and transformation, together with a job of viral brokers. In this angle, we revise the traces of proof that steered a pathogenetic position in LGLL of the publicity to retroviruses and that recognized Epstein Barr Virus (EBV) in different NK cell leukemias and lymphomas and deal with the contrasting information about the significance of viral brokers in CLPD-NK.
EBV was detected in aggressive NK leukemias however not in the indolent CLPD-NK, the place seroreactivity towards HTLV-1 retrovirus envelope BA21 protein antigens has been reported in sufferers, though missing clear proof of HTLV an infection. We subsequent current unique outcomes of complete exome sequencing information evaluation that failed to determine viral sequences in CLPD-NK. We not too long ago demonstrated that proliferating NK cells of sufferers harbor a number of somatic lesions probably contributing to maintain NK cell proliferation.
Thus, we discover whether or not “neoantigens” comparable to the BA21 antigen might be generated by aberrancies current in the leukemic clone. In gentle of the literature and new information, we evaluated the intriguing speculation that NK cell activation will be attributable to retroviral brokers situated outdoors the hematopoietic compartment and on the potential mechanisms concerned with the prospects of immunotherapy-based approaches to restrict the progress of NK cells in CLPD-NK illness.
 Alpha-bungarotoxin, CF405s |
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| 00002-100ug | Biotium | 100uG | EUR 161 |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF680r |
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| 9-00003 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF680r |
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| 9-00003 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF640r |
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| 9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF640r |
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| 9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Alpha-bungarotoxin CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Alpha-bungarotoxin CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin |
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| 00010-1 | Biotium | 1MG | EUR 168 |
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Description: Minimum order quantity: 1 unit of 1MG |
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 Fluorescein-Alpha-bungarotoxin |
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| 00011 | Biotium | 500uG | EUR 367 |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Tetramethylrhodamine-Alpha-bungarotoxin |
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| 00012 | Biotium | 500uG | EUR 383 |
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Description: Minimum order quantity: 1 unit of 500uG |
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) Fluorescein-alpha-bungarotoxin: (10x50ug) |
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| 00013 | Biotium | 10ST | EUR 417 |
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Description: Minimum order quantity: 1 unit of 10ST |
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) Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug) |
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| 00014 | Biotium | 10ST | EUR 466 |
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Description: Minimum order quantity: 1 unit of 10ST |
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: (500ug)) Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug) |
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| 00015 | Biotium | 500uG | EUR 466 |
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Description: Minimum order quantity: 1 unit of 500uG |
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: (10x50ug)) Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug) |
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| 00016 | Biotium | 10ST | EUR 523 |
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Description: Minimum order quantity: 1 unit of 10ST |
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 Biotin-xx-a-bungarotoxin |
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| 00017 | Biotium | 500uG | EUR 433 |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Biotin-cAMP, diisopropylethylammonium salt: |
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| 00020 | Biotium | 1MG | EUR 314 |
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Description: Minimum order quantity: 1 unit of 1MG |
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) Biotin-cAMP, diisopropylethylammonium salt: (20x50ug) |
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| 00020-1 | Biotium | 20ST | EUR 418 |
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Description: Minimum order quantity: 1 unit of 20ST |
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 Biotin-cGMP, diisopropylethylammonium salt: |
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| 00021 | Biotium | 1MG | EUR 344 |
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Description: Minimum order quantity: 1 unit of 1MG |
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) Biotin-cGMP, diisopropylethylammonium salt: (20x50ug) |
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| 00021-1 | Biotium | 20ST | EUR 448 |
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Description: Minimum order quantity: 1 unit of 20ST |
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 Cyanine 644-cAMP: |
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| 00022 | Biotium | 1MG | EUR 491 |
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Description: Minimum order quantity: 1 unit of 1MG |
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) Cyanine 644-cAMP: (20x50ug) |
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| 00022-1 | Biotium | 20ST | EUR 625 |
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Description: Minimum order quantity: 1 unit of 20ST |
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 Fluorescein Methotrexate, triammonium salt: |
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| 00023 | Biotium | 1MG | EUR 281 |
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Description: Minimum order quantity: 1 unit of 1MG |
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 Staurosporine |
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| 00025 | Biotium | 100uG | EUR 139 |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF543 |
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| 00026 | Biotium | 500uG | EUR 494 |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Rhodamine phalloidin 300u |
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| 00027 | Biotium | 300 | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300 |
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 Biotin-xx-phalloidin |
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| 00028 | Biotium | 100U | EUR 428 |
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Description: Minimum order quantity: 1 unit of 100U |
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 Fluorescein-phalloidin |
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| 00030 | Biotium | 300U | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300U |
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 Rhodamine 110 phalloidin |
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| 00032 | Biotium | 300ST | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300ST |
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 Phalloidin) Sulforhodamine 101 (Texas-Red) Phalloidin |
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| 00033 | Biotium | 300EU | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300EU |
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 Phalloidin, CF405M |
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| 00034 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF405M |
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| 00034-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 CF488A-cAMP |
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| 00036 | Biotium | 100ug | EUR 172 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 CF640R-cAMP |
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| 00037 | Biotium | 100ug | EUR 172 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Phalloidin, CF555 |
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| 00040 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF555 |
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| 00040-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF647 |
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| 00041 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF647 |
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| 00041-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF488A |
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| 00042 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF488A |
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| 00042-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF543 |
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| 00043 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF543 |
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| 00043-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF568 |
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| 00044 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF568 |
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| 00044-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF594 |
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| 00045 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF594 |
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| 00045-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF633 |
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| 00046 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF633 |
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| 00046-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF660R |
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| 00047 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660R |
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| 00047-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF680R |
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| 00048 | Biotium | 300U | EUR 466 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680R |
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| 00048-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF350 |
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| 00049 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF350 |
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| 00049-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF640R |
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| 00050 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF640R |
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| 00050-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF532 |
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| 00051 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF532 |
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| 00051-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF660C |
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| 00052 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660C |
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| 00052-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF680 |
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| 00053 | Biotium | 300U | EUR 466 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680 |
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| 00053-T | Biotium | 50U | EUR 147 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF430 |
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| 00054 | Biotium | 300U | EUR 449 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF430 |
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| 00054-T | Biotium | 50U | EUR 139 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF440 |
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| 00055 | Biotium | 300U | EUR 449 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF440 |
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| 00055-T | Biotium | 50U | EUR 139 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Cholera Toxin Subunit B, CF488A conjugate |
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| 00070 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF568 conjugate |
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| 00071 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF594 conjugate |
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| 00072 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF640R conjugate |
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| 00073 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF532 conjugate |
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| 00074 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF543 conjugate |
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| 00075 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF620R conjugate |
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| 00076 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF633 conjugate |
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| 00077 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF660R conjugate |
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| 00078 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF680R conjugate |
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| 00079 | Biotium | 100ug | EUR 282 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Human Transferrin, CF488A conjugate |
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| 00081 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF543 conjugate |
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| 00082 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF568 conjugate |
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| 00083 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF594 conjugate |
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| 00084 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF640R conjugate |
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| 00085 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF680R conjugate |
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| 00086 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF750 conjugate |
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| 00087 | Biotium | 1mg | EUR 155 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 HIV-1 tat recombinant antigen |
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| 00110-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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HIV-1 tat recombinant antigen |
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| 00110-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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 HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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 HIV-1 nef recombinant antigen |
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| 00112-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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HIV-1 nef recombinant antigen |
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| 00112-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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 HIV-1 env gp41 recombinant antigen |
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| 00113-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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HIV-1 env gp41 recombinant antigen |
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| 00113-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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 HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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 HCV core recombinant antigen |
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| 00115-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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HCV core recombinant antigen |
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| 00115-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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 HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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 HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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 HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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 HCV NS4 recombinant antigen NS4a+b |
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| 00116-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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HCV NS4 recombinant antigen NS4a+b |
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| 00116-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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 HCV NS4 recombinant antigen NS4a+b, Biotin |
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| 00116-V-B-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
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HCV NS4 recombinant antigen NS4a+b, Biotin |
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| 00116-V-B-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
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 HCV NS4 recombinant antigen NS4a+b, FITC |
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| 00116-V-F-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
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HCV NS4 recombinant antigen NS4a+b, FITC |
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| 00116-V-F-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
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 HCV NS4 recombinant antigen NS4a+b, Rhodamine |
|||
| 00116-V-R-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
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HCV NS4 recombinant antigen NS4a+b, Rhodamine |
|||
| 00116-V-R-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
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 HCV NS3 recombinant antigen |
|||
| 00117-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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HCV NS3 recombinant antigen |
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| 00117-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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 HBV core recombinant antigen |
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| 00120-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
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HBV core recombinant antigen |
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| 00120-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
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 HBV core recombinant antigen, Delta |
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| 00121-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
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HBV core recombinant antigen, Delta |
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| 00121-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
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 HBV surface recombinant antigen HBsAg |
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| 00122-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
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HBV surface recombinant antigen HBsAg |
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| 00122-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
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 HBV surface recombinant antigen HBsAg antigen |
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| 00123-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
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HBV surface recombinant antigen HBsAg antigen |
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| 00123-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
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HBV surface recombinant antigen HBsAg antigen |
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| 00124-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
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HBV surface recombinant antigen HBsAg antigen |
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| 00124-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
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 ORF2 recombinant antigen) HEV (Birma) ORF2 recombinant antigen |
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| 00131-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
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HEV (Birma) ORF2 recombinant antigen |
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| 00131-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
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HEV (Birma) ORF2 recombinant antigen |
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| 00132-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
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HEV (Birma) ORF2 recombinant antigen |
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| 00132-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
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This part 2 research with Simon’s two-stage design evaluated daratumumab in sufferers with histologically confirmed extranodal NKTCL, nasal kind, per WHO classification that was refractory to or relapsed after ≥ 1 line of chemotherapy, who weren’t candidates for different remedy modalities. All sufferers obtained daratumumab 16 mg/kg intravenously as soon as weekly for Cycles 1 and 2, each different week for Cycles Three by way of 6, and each four weeks thereafter till development or unacceptable toxicity; all cycles had been 28 days. The main finish level was goal response price (ORR) based mostly on blinded impartial central evaluate per Revised Criteria for Response Assessment of Hodgkin and non-Hodgkin Lymphoma (Lugano classification).